Others titles

  • New ATC Code 2020
  • New ATC Update and Alterations
  • New DDD Updates and Alterations


  • ATC Classification
  • ATC Alterations
  • DDD Alterations
  • New ATC
  • New DDD

Defined Daily Dose Alterations 2005 to 2020

This dataset contains the DDD (Defined Daily Dose) Alterations from 2005 to 2020.

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Cumulative overview of all DDD alterations performed in the period 2005 to 2020. The year changed is when the alterations were implemented in the ATC/DDD Index. Please note that a DDD may have changed more than once for some ATC codes. The ATC codes are current codes. For substances where the DDD is changed twice the new DDD which is not according to the current value is marked with an asterisk (*).

In 1996, WHO recognized the need to develop the use of the ATC/DDD system as an international standard for drug utilization studies. The Centre was therefore linked directly to WHO Headquarters in Geneva instead of the WHO Regional Office for Europe in Copenhagen. This was seen as important to allow close integration of international drug utilization studies and WHO’s initiatives to achieve universal access to needed drugs and rational use of drugs particularly in developing countries. Access to standardized and validated information on drug use is essential to allow audit of patterns of drug utilization, identification of problems, educational or other interventions and monitoring of the outcomes of the interventions.

When the decision on globalizing the ATC/DDD system was taken, the WHO Division of Drug Management and Policies established the WHO International Working Group for Drug Statistics Methodology. The WHO Collaborating Centre for Drug Statistics Methodology receives expert advice from the Working Group.

About this Dataset

Data Info

Date Created


Last Modified




Update Frequency


Temporal Coverage


Spatial Coverage

United States


John Snow Labs; WHO Collaborating Centre for Drug Statistics Methodology;

Source License URL

Source License Requirements


Source Citation



ATC Classification, ATC/DDD, ATC Alterations, DDD Alterations, New ATC, New DDD

Other Titles

New ATC Code 2020, New ATC Update and Alterations, New DDD Updates and Alterations

Data Fields

Name Description Type Constraints
Substance_NameSubstances Indicated for Rare Disorders with Individual Dosingstring-
Previous_DDDPrevious Rate of Defined Daily Dosenumberlevel : Ratio
Previous_UnitPrevious Unit used for DDD (g = gram, mg milligram, MU = million units, TU = thousand units, U = unit)string-
Previous_Administration_RoutePrevious Administration Route for DDD (N = nasal, Inhal = Inhalation , O = oral, P = parenteral, R = rectal, TD = transdermal, SL = sublingual/buccal)string-
New_DDDNew Rate of Defined Daily Dose. Various Sources are used to get the Best Overview of the Actual or Expected use of a Substance.numberlevel : Ratio
New_UnitNew Unit Used for the New DDD (g = gram, mg milligram, MU = million units, TU = thousand units, U = unit)string-
New_Administration_RouteNew Administration Route for the New DDD (N = nasal, Inhal = Inhalation , O = oral, P = parenteral, TD = transdermal, SL = sublingual/buccal)string-
Present_ATC_CodePresent ATC Codestring-
Year_ChangedYear when DDD was altereddate-

Data Preview

Substance NamePrevious DDDPrevious UnitPrevious Administration RouteNew DDDNew UnitNew Administration RoutePresent ATC CodeYear Changed
amoxicillin and beta-lactamase inhibitor1.0gO1.5gOJ01CR022019
amoxicillin and enzyme inhibitor1.0gP3.0gPJ01CR022005
ampicillin and enzyme inhibitor2.0gP6.0gPJ01CR012017