Proven Drug Targets Converted to Human SwissProt Accessions

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This dataset is a supplementary data from “Novelty in the target landscape of the pharmaceutical industry” (2013). The listing of proven drug targets is converted to 248 human Swiss-Prot accessions.

Complexity

This dataset is a selection of proven drug target lists extracted from the literature, Novelty in the target landscape of the pharmaceutical industry; as a supplementary data. The criteria for inclusion are drug target coverage for the human proteins.

There are utilities that can be explored in this dataset including the two: a) following the database links and b) comparing them for intersects (protein IDs in common) and differentials (protein IDs unique to particular lists or subsets). This can be extended to comparisons with lists that may be generated in the course of studying other published work (e.g. expression data or disease association gene candidates).

The metadata descriptions are minimal since context is provided either in the references and/or the download descriptions for the appropriate databases. The lists are Excel sheets of UniProtKB, HGNC and ChEMBL live links. These entry points should be able to get to the most from other sources.

Lists that are not UniProtKB Accessions are normalized to these (e.g. mappings of Human Gene Nomenclature Committee (HGNC) Symbols or Entrez Gene IDs (EGID) to UniProtKB). They are then filtered to human and Swiss-Prot (i.e. any TrEMBL entries are removed) and to approved drug targets if this is an option in the original list. In such cases, lists that are hosted thus become transformations, rather than direct facsimiles, of the primary sources. Given such ID cross-mappings are not perfect; absolute correctness cannot be guaranteed. Versions, however, are supplied in good faith and the originals are available in every case.

Date Created

2013-08-12

Last Modified

2017-01-27

Version

2017-01-27

Update Frequency

Irregular

Temporal Coverage

N/A

Spatial Coverage

N/A

Source

John Snow Labs => International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS) Guide to PHARMACOLOGY

Source License URL

John Snow Labs Standard License

Source License Requirements

The Guide to PHARMACOLOGY database is licensed under the Open Data Commons Open Database License (ODbL). Its contents are licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported license.

Source Citation

Agarwal P, Sanseau P, Cardon LR. Novelty in the target landscape of the pharmaceutical industry. PMID 23903214 DOI 10.1038/nrd4089

Keywords

List of Proteins, Drug Definition, Drug Information, Medication Information, Protein Database, Free Database

Other Titles

Proven Drug Targets Human SwissProt Accessions, Drug Targets ChEMBL HGNC, ChEMBL HGNC Drug Targets Database

Name Description Type Constraints
Entry_ReportThis subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.stringunique : 1 required : 1
Protein_NamesThis subsection of the Protein Names on ‘Names and Taxonomy’ section provides a list of names of the human protein, from commonly used to obsolete, to allow unambiguous identification of a protein. This subsection may also include information on the activity of the protein, such as a precise description of the catalytic mechanism of enzymes, or information about individual protein chains or functional domains contained within it, if pertinent.stringrequired : 1
Cross_Reference_HGNC_IdHGNC ID for each protein name.stringrequired : 1
Cross_Reference_HGNC_URLLinks to the HGNC databases cross-referenced in UniProtKB Swiss-Prot > HGNCstringrequired : 1
Cross_Reference_CHEMBL_IdChEMBL ID for each protein name.string-
Cross_Reference_CHEMBL_URLLinks to the ChEMBL databases cross-referenced in UniProtKB Swiss-Prot > CHeMBLstring-
Entry_ReportProtein_NamesCross_Reference_HGNC_IdCross_Reference_HGNC_URLCross_Reference_CHEMBL_IdCross_Reference_CHEMBL_URL
O60494CubilinHGNC:2548, CUBNhttp://www.genenames.org/data/hgnc_data.php?hgnc_id=2548
P01350GastrinHGNC:4164, GASThttp://www.genenames.org/data/hgnc_data.php?hgnc_id=4164
P15941Mucin-1HGNC:7508, MUC1http://www.genenames.org/data/hgnc_data.php?hgnc_id=7508
P51959Cyclin-G1HGNC:1592, CCNG1http://www.genenames.org/data/hgnc_data.php?hgnc_id=1592
P01258CalcitoninHGNC:1437, CALCAhttp://www.genenames.org/data/hgnc_data.php?hgnc_id=1437
P16070CD44 antigenHGNC:1681, CD44http://www.genenames.org/data/hgnc_data.php?hgnc_id=1681
P01579Interferon gammaHGNC:5438, IFNGhttp://www.genenames.org/data/hgnc_data.php?hgnc_id=5438
P07204ThrombomodulinHGNC:11784, THBDhttp://www.genenames.org/data/hgnc_data.php?hgnc_id=11784
P06454Prothymosin alphaHGNC:9623, PTMAhttp://www.genenames.org/data/hgnc_data.php?hgnc_id=9623
P01270Parathyroid hormoneHGNC:9606, PTHhttp://www.genenames.org/data/hgnc_data.php?hgnc_id=9606