Others titles
- Protein-protein interaction database
- Species wide interactome
- Annotated major model systems protein-protein interaction
- Protein Database Protein Protein Interactions
- Protein Analysis Protein Protein Interactions
- Protein Expression Protein Protein Interactions
- Protein C Protein Protein Interactions
Keywords
- PPI
- Interactome
- Protein protein docking
- Interactor
- Protein database
- Protein science
- Protein Database
- Protein Analysis
- Protein Expression
- Protein C
Biochemical Protein Protein Interactions

This dataset includes all protein-protein interactions as well as associated annotation data obtained from the Biological General Repository for Interaction databases (BIOGRID) for major model organisms species, including involved experimental systems used to disclose the interaction. The data is a curation of thousands of publications of research experiments that found a link (interaction) between two proteins.
Get The Data
- Research
Non-Commercial,
Share-Alike,
Attribution Free Forever
- Commercial
Commercial Use,
Remix & Adapt,
White Label Log in to download
Description
BioGRID interactions are recorded as relationships between two proteins or genes (i.e. they are binary relationships) with an evidence code that supports the interaction and a publication reference. The term “interaction” includes, as well as direct physical binding of two proteins, co-existence in a stable complex and genetic interaction. It should not be assumed that the interaction reported in BioGRID is direct and physical in nature; the experimental system definitions below indicate the nature of the supporting evidence for an interaction between the two biological entities. It should also be noted that some interactions in BioGRID have various levels of evidential support. BioGRID simply curates the result of the experiment from the publication and does not guarantee that any individual interaction is true, well-established or the current consensus view of the community. Curating all available evidence supporting an interaction enables orthogonal data from various sources to be collated, allowing users of the database to decide confidence in the existence and/or physiological relevance of that interaction.
The Biological General Repository for Interaction Datasets (BioGRID) is a public database that archives and disseminates genetic and protein interaction data from model organisms and humans (thebiogrid.org). BioGRID currently holds over 980,000 interactions curated from both high-throughput datasets and individual focused studies, as derived from over 55,000 publications in the primary literature. Complete coverage of the entire literature is maintained for budding yeast (S. cerevisiae), fission yeast (S. pombe) and thale cress (A. thaliana), and efforts to expand curation across multiple metazoan species are underway. Current curation drives are focused on particular areas of biology to enable insights into conserved networks and pathways that are relevant to human health. BioGRID provides interaction data from several model organism databases, resources such as Entrez-Gene, SGD, TAIR, FlyBase and other interaction meta-databases.
The dataset contains protein-protein interactions, noting the official symbol and aliases for every interactor as well as the experimental system used to disclose the interaction. Reference of the publication is given as first author and PubMed ID and the organisms involved are also specified.
Description source: Chatr-Aryamontri A, Oughtred R, Boucher L, Rust J, Chang C, Kolas NK, O’Donnell L, Oster S, Theesfeld C, Sellam A, Stark C, Breitkreutz BJ, Dolinski K, Tyers M. The BioGRID interaction database: 2017 update. Nucleic Acids Res. 2016 Dec 14;2017(1) [ Pubmed, NAR ]
About this Dataset
Data Info
Date Created | 2015-12-25 |
---|---|
Last Modified | 2023-08-30 |
Version | 4.4.225 |
Update Frequency |
Quarterly |
Temporal Coverage |
N/A |
Spatial Coverage |
N/A |
Source | John Snow Labs; Biological General Repository for Interaction Datasets; |
Source License URL | |
Source License Requirements |
N/A |
Source Citation |
N/A |
Keywords | PPI, Interactome, Protein protein docking, Interactor, Protein database, Protein science, Protein Database, Protein Analysis, Protein Expression, Protein C |
Other Titles | Protein-protein interaction database, Species wide interactome, Annotated major model systems protein-protein interaction, Protein Database Protein Protein Interactions, Protein Analysis Protein Protein Interactions, Protein Expression Protein Protein Interactions, Protein C Protein Protein Interactions |
Data Fields
Name | Description | Type | Constraints |
---|---|---|---|
BioGRID_ID_Interactor_A | Identification number of protein A in the BioGRID database. | string | required : 1 |
BioGRID_ID_Interactor_B | Identification number of protein B in the BioGRID database. | string | required : 1 |
Official_Symbol_Interactor_A | Official symbol name for interacting protein A | string | - |
Official_Symbol_Interactor_B | Official symbol name for interacting protein B | string | - |
Aliases_Interactor_A | List of common names for interacting protein A, separated by '|' | string | - |
Aliases_Interactor_B | List of common names for interacting protein B, separated by '|' | string | - |
Experimental_System | System in which the interaction was shown. | string | required : 1 |
Source | Publication in which interaction was reported and presented as first author and date. | string | - |
Pubmed_ID | Identification number of the text describing the experiment published in PubMed database as evidence of the interaction. PubMed is a US National Library of Medicine citation database that contains millions of abstracts, references and full text links of biomedical literature from different trusted sources. | string | required : 1 |
Organism_Interactor_A_ID | National Center for Biotechnology Information (NCBI) ID of Gene A Organism. | integer | level : Nominalrequired : 1 |
Organism_Interactor_B_ID | National Center for Biotechnology Information (NCBI) ID of Gene A Organism. | integer | level : Nominalrequired : 1 |
Data Preview
BioGRID ID Interactor A | BioGRID ID Interactor B | Official Symbol Interactor A | Official Symbol Interactor B | Aliases Interactor A | Aliases Interactor B | Experimental System | Source | Pubmed ID | Organism Interactor A ID | Organism Interactor B ID |
ETG6416 | ETG2318 | MAP2K4 | FLNC | JNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1|SKK1 | ABP-280|ABP280A|ABPA|ABPL|FLN2|MFM5|MPD4 | Two-hybrid | Marti A (1997) | 9006895 | 9606 | 9606 |
ETG84665 | ETG88 | MYPN | ACTN2 | CMD1DD|CMH22|MYOP|RCM4 | CMD1AA | Two-hybrid | Bang ML (2001) | 11309420 | 9606 | 9606 |
ETG90 | ETG2339 | ACVR1 | FNTA | ACTRI|ACVR1A|ACVRLK2|ALK2|FOP|SKR1|TSRI | FPTA|PGGT1A|PTAR2 | Two-hybrid | Wang T (1996) | 8599089 | 9606 | 9606 |
ETG2624 | ETG5371 | GATA2 | PML | DCML|IMD21|MONOMAC|NFE1B | MYL|PP8675|RNF71|TRIM19 | Two-hybrid | Tsuzuki S (2000) | 10938104 | 9606 | 9606 |
RP4-547C9.3 | ETG6774 | RPA2 | STAT3 | REPA2|RP-A p32|RP-A p34|RPA32 | ADMIO|APRF|HIES | Two-hybrid | Kim J (2000) | 10875894 | 9606 | 9606 |
ETG375 | ETG23163 | ARF1 | GGA3 | Two-hybrid | Dell'Angelica EC (2000) | 10747089 | 9606 | 9606 | ||
ETG377 | ETG23647 | ARF3 | ARFIP2 | POR1 | Two-hybrid | Kanoh H (1997) | 9038142 | 9606 | 9606 | |
ETG377 | ETG27236 | ARF3 | ARFIP1 | HSU52521 | Two-hybrid | Kanoh H (1997) | 9038142 | 9606 | 9606 | |
ETG54464 | ETG226 | XRN1 | ALDOA | Sep-01 | ALDA|GSD12|HEL-S-87p | Two-hybrid | Lehner B (2004) | 15231747 | 9606 | 9606 |
ETG351 | ETG10513 | APP | APPBP2 | AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2 | APP-BP2|HS.84084|PAT1 | Two-hybrid | Zheng P (1998) | 9843960 | 9606 | 9606 |