Others titles

  • Pharmacology Targeted Therapy and Family List Identification
  • Pharmacology Complete Target Sheets and Family List Identification
  • Pharmacology Molecular Targeted Therapy

Keywords

  • Targeted Therapy
  • Target Sheets
  • Molecular Targeted Therapy
  • Drug Molecules

Pharmacology Complete Target and Family List Identification

This dataset shows the complete target and family list from the Guide to PHARMACOLOGY; an online, open-access portal to pharmacological information on all the human targets of prescription drugs, which is the product from the collaboration of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS).

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Description

The data types captured in this dataset include target nomenclature, pharmacological data, and ligand structures. Organisms isolated for this data are from human, mouse, and rat. There are 6929 human proteins and rat and mouse orthologues (i.e. 84% of a maximum projected three-species where the 16% either do not have Swiss-ProtIDs yet or IUPHAR curation indicates that the orthology relationship is more complex than 1:1 case) in this database. Information from mouse and rat are presented as rodent binding data are the most common type mentioned in papers, in addition or as a replacement for human data.

In future versions, the plan is to add resources for education and training in pharmacological principles and techniques along with research guidelines and overviews of key topics. It is the hope of IUPHAR/BPS Guide to PHARMACOLOGY to be useful for researchers and students in pharmacology and drug discovery and provide the general public with accurate information on the basic science underlying drug action.

The information provided in this dataset shows the initial view or landing pages for each target family that provides expert-curated overviews of the key properties and selective ligands and tool compounds available. Additional information can be found also in other databases including Ensembl, UniProt, PubChem, ChEMBL, and DrugBank, as well as curated chemical information and literature citations in PubMed.

In this dataset, the target class or “target” refers to a record in the database that has been resolved to a UniProtKB/SwissProt ID as the primary identifier. Target class content includes the following 7TM receptors, Nuclear hormone receptors, Catalytic receptors, Ligand-gated ion channels, Voltage-gated ion channels, Other ion channels, Enzymes (all), Transporters, Kinases, Proteases and Other proteins. Note that not all 7TM receptor records are unequivocally assigned as GPCRs, but for convenience, they are referred to generally as GPCRs or G protein-coupled receptors in the study.

As stated in the study, the term “target” in the database also includes verified targets for the MMOAs for drugs used to treat human diseases, newer receptor-ligand pairings judged to be credible by a dedicated NC-IUPHAR subcommittee, and human targets identified by the orthologue activity mapping where only non-human binding data are available. In addition, the database also contains the targets of undesirable ligand interactions known as anti-targets as well as emergent targets which are proteins that do not have sufficient validation data to be considered bonafide therapeutic drug targets but are nonetheless being investigated to both establish their normal function and possible disease involvement.

This updated database enables a more detailed exploration of statistics as it provides a detailed overview of the database and allows comparison with other resources, communication of results to users and funders, measures progress and identifies areas for expansion.

About this Dataset

Data Info

Date Created

2011

Last Modified

2020-04-12

Version

2020.4

Update Frequency

Quarterly

Temporal Coverage

N/A

Spatial Coverage

N/A

Source

John Snow Labs; International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS) Guide to PHARMACOLOGY;

Source License URL

Source License Requirements

N/A

Source Citation

Southan C, Sharman JL, Benson HE, Faccenda E, Pawson AJ, Alexander SPH, Buneman OP, Davenport AP, McGrath JC, Peters JA, Spedding M, Catterall WA, Fabbro D, Davies JA; NC-IUPHAR. (2016) The IUPHAR/BPS Guide to PHARMACOLOGY in 2016 towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucl. Acids Res. 44 (Database Issue) D1054-68

Keywords

Targeted Therapy, Target Sheets, Molecular Targeted Therapy, Drug Molecules

Other Titles

Pharmacology Targeted Therapy and Family List Identification, Pharmacology Complete Target Sheets and Family List Identification, Pharmacology Molecular Targeted Therapy

Data Fields

Name Description Type Constraints
Type_or_Target_ClassThe target class or “target” refers to a record in the database that has been resolved to a UniProtKB/SwissProt ID as the primary identifier. Target class content includes the following 7TM receptors, Nuclear hormone receptors, Catalytic receptors, Ligand-gated ion channels, Voltage-gated ion channels, Other ion channels, Enzymes (all), Transporters, Kinases, Proteases and Other proteins. Not all 7TM receptor records are unequivocally assigned as GPCRs, but for convenience, they are referred to generally as GPCRs or G protein-coupled receptors in the database.stringrequired : 1
Family_IdThe Guide to Pharmacology (GtP) family identifierintegerlevel : Nominalrequired : 1
Family_NameThe Guide to Pharmacology (GtP) family namestringrequired : 1
Target_IdThe Guide to Pharmacology (GtP) target identifierintegerlevel : Nominalrequired : 1
Target_NameThe Guide to Pharmacology (GtP) target name, usually the IUPHAR recommended name or a provisional name (for information on target nomenclature see the online help documentation)stringrequired : 1
SubunitsThe names of any subunits that make up a multimeric proteinstring-
Target_Systematic_NameA systematic name associated with the targetstring-
Target_Abbreviated_NameA commonly used abbreviation of the target namestring-
SynonymsOther names commonly used in the literaturestring-
HUGO_Gene_Nomenclature_Committee_IdThe HUGO Gene Nomenclature Committee (HGNC) gene identifierstring-
HUGO_Gene_Nomenclature_Committee_SymbolThe HGNC gene symbolstring-
HUGO_Gene_Nomenclature_Committee_NameThe HGNC gene namestring-
Human_Genetic_LocalisationThe genetic location of the encoding gene in humanstring-
Human_Nucleotide_RefSeqThe RefSeq identifier for the human mRNA sequencestring-
Human_Protein_RefSeqThe RefSeq identifier for the human protein sequencestring-
Human_SwissProtThe UniProtKB/SwissProt Accession for the human protein sequencestring-
Human_Entrez_GeneThe human Entrez Gene identifierstring-
Rat_Genome_Database_IdThe Rat Genome Database (RGD) gene identifierstring-
Rat_Genome_Database_SymbolThe RGD gene symbolstring-
Rat_Genome_Database_NameThe RGD gene namestring-
Rat_Genetic_LocalisationThe genetic location of the encoding gene in ratstring-
Rat_Nucleotide_RefSeqThe RefSeq identifier for the rat mRNA sequencestring-
Rat_Protein_RefSeqThe RefSeq identifier for the rat protein sequencestring-
Rat_SwissProtThe UniProtKB/SwissProt Accession for the rat protein sequencestring-
Rat_Entrez_GeneThe rat Entrez Gene identifierstring-
Mouse_Genome_Informatics_IdThe Mouse Genome Informatics (MGI) gene identifierstring-
Mouse_Genome_Informatics_SymbolThe MGI gene symbolstring-
Mouse_Genome_Informatics_NameThe MGI gene namestring-
Mouse_Genetic_LocalisationThe genetic location of the encoding gene in mousestring-
Mouse_Nucleotide_RefSeqThe RefSeq identifier for the mouse mRNA sequencestring-
Mouse_Protein_RefSeqThe RefSeq identifier for the mouse protein sequencestring-
Mouse_SwissProtThe UniProtKB/SwissProt Accession for the mouse protein sequencestring-
Mouse_Entrez_GeneThe mouse Entrez Gene identifierstring-

Data Preview

Type or Target ClassFamily IdFamily NameTarget IdTarget NameSubunitsTarget Systematic NameTarget Abbreviated NameSynonymsHUGO Gene Nomenclature Committee IdHUGO Gene Nomenclature Committee SymbolHUGO Gene Nomenclature Committee NameHuman Genetic LocalisationHuman Nucleotide RefSeqHuman Protein RefSeqHuman SwissProtHuman Entrez GeneRat Genome Database IdRat Genome Database SymbolRat Genome Database NameRat Genetic LocalisationRat Nucleotide RefSeqRat Protein RefSeqRat SwissProtRat Entrez GeneMouse Genome Informatics IdMouse Genome Informatics SymbolMouse Genome Informatics NameMouse Genetic LocalisationMouse Nucleotide RefSeqMouse Protein RefSeqMouse SwissProtMouse Entrez Gene
gpcr15-Hydroxytryptamine receptors15-HT<sub>1A</sub> receptorADRBRL1|5-HT1A|ADRB2RL1|serotonin receptor 1A|Gpcr18|5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled5286HTR1A5-hydroxytryptamine receptor 1A5q12.3NM_000524NP_000515P0890833502845.0Htr1a5-hydroxytryptamine receptor 1A2q13NM_012585NP_036717P1932724473.0MGI:96273Htr1a5-hydroxytryptamine (serotonin) receptor 1A13 56.92 cMNM_008308NP_032334Q6426415550.0
gpcr15-Hydroxytryptamine receptors25-HT<sub>1B</sub> receptor5-HT1B|5-HT1DB|HTR1D2|5-HT1B serotonin receptor|serotonin receptor 1B|5-HT<sub>1D&beta;</sub>|5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled5287HTR1B5-hydroxytryptamine receptor 1B6q14.1NM_000863NP_000854P2822233512846.0Htr1b5-hydroxytryptamine receptor 1B8q31NM_022225NP_071561P2856425075.0MGI:96274Htr1b5-hydroxytryptamine (serotonin) receptor 1B9 44.61 cMNM_010482NP_034612P2833415551.0
gpcr15-Hydroxytryptamine receptors35-HT<sub>1D</sub> receptor5-HT<sub>1D&alpha;</sub>|HTRL|5-HT1D|HT1DA|serotonin receptor 1D|Gpcr14|Htr1db|5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled5289HTR1D5-hydroxytryptamine receptor 1D1p36.12NM_000864NP_000855P2822133522847.0Htr1d5-hydroxytryptamine receptor 1D5q36NM_012852NP_036984P2856525323.0MGI:96276Htr1d5-hydroxytryptamine (serotonin) receptor 1D4 68.74 cMNM_008309NP_032335Q6122415552.0
gpcr15-Hydroxytryptamine receptors45-ht<sub>1e</sub> receptor5-HT<sub>1E</sub><sub>&alpha;</sub>|5-HT1E|5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled5291HTR1E5-hydroxytryptamine receptor 1E6q14.3NM_000865NP_000856P285663354
gpcr15-Hydroxytryptamine receptors55-HT<sub>1F</sub> receptor5-HT<sub>1E&beta;</sub>|5-HT<sub>6</sub>|5-HT1F|HTR1EL|serotonin receptor 1F|5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled5292HTR1F5-hydroxytryptamine receptor 1F3p12NM_000866NP_000857P30939335571083.0Htr1f5-hydroxytryptamine receptor 1F11p12NM_021857NP_068629P3094060448.0MGI:99842Htr1f5-hydroxytryptamine (serotonin) receptor 1F16 37.1 cMNM_008310NP_032336Q0228415557.0
gpcr15-Hydroxytryptamine receptors65-HT<sub>2A</sub> receptor'D' receptor|5Ht-2|serotonin 5HT-2 receptor|serotonin receptor 2A|5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled5293HTR2A5-hydroxytryptamine receptor 2A13q14.2NM_000621NP_000612P28223335661800.0Htr2a5-hydroxytryptamine receptor 2A15q11NM_017254NP_058950P1484229595.0MGI:109521Htr2a5-hydroxytryptamine (serotonin) receptor 2A14 39.37 cMNM_172812NP_766400P3536315558.0
gpcr15-Hydroxytryptamine receptors75-HT<sub>2B</sub> receptor5-HT<sub>2F</sub>|5-HT2B|serotonin receptor 2B|stomach fundus serotonin receptor|5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled5294HTR2B5-hydroxytryptamine receptor 2B2q37.1NM_000867NP_000858P41595335761801.0Htr2b5-hydroxytryptamine receptor 2B9q35NM_017250NP_058946P3099429581.0MGI:109323Htr2b5-hydroxytryptamine (serotonin) receptor 2B1 C5NM_008311NP_032337Q0215215559.0
gpcr15-Hydroxytryptamine receptors85-HT<sub>2C</sub> receptor5-HT<sub>1C</sub>|5-HT2C|HTR1C|5-HTR2C|5-hydroxytryptamine receptor 1C|serotonin 1c receptor|serotonin receptor 2C|5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled5295HTR2C5-hydroxytryptamine receptor 2CXq23NM_000868NP_000859P2833533582848.0Htr2c5-hydroxytryptamine receptor 2CXq34NM_012765NP_036897P0890925187.0MGI:96281Htr2c5-hydroxytryptamine (serotonin) receptor 2CX 68.46 cMNM_008312NP_032338P3496815560.0
gpcr15-Hydroxytryptamine receptors95-HT<sub>4</sub> receptor5-HT4|serotonin receptor 4|5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled5299HTR45-hydroxytryptamine receptor 45q32NM_000870NP_000861Q1363933602850.0Htr45-hydroxytryptamine receptor 418q12.1NM_012853NP_036985Q6275825324.0MGI:109246Htr45 hydroxytryptamine (serotonin) receptor 418 E1NM_008313NP_032339P9728815562.0
gpcr15-Hydroxytryptamine receptors105-HT<sub>5A</sub> receptor5-HT<sub>5&alpha;</sub>|5HT<sub>5-</sub>|5-HT-5A|MR22|serotonin receptor 5A|Htr5|5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled5300HTR5A5-hydroxytryptamine receptor 5A7q36.2NM_024012NP_076917P4789833612851.0Htr5a5-hydroxytryptamine receptor 5A4q11NM_013148NP_037280P3536425689.0MGI:96283Htr5a5-hydroxytryptamine (serotonin) receptor 5A5 13.24 cMNM_008314NP_032340P3096615563.0