Pharmacology Complete Target and Family List Identification

$199 / year

This dataset shows the complete target and family list from the Guide to PHARMACOLOGY; an online, open-access portal to pharmacological information on all the human targets of prescription drugs, which is the product from the collaboration of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS).

Complexity

The data types captured in this dataset include target nomenclature, pharmacological data, and ligand structures. Organisms isolated for this data are from human, mouse, and rat. There are 6929 human proteins and rat and mouse orthologues (i.e. 84% of a maximum projected three-species where the 16% either do not have Swiss-ProtIDs yet or IUPHAR curation indicates that the orthology relationship is more complex than 1:1 case) in this database. Information from mouse and rat are presented as rodent binding data are the most common type mentioned in papers, in addition or as a replacement for human data.

In future versions, the plan is to add resources for education and training in pharmacological principles and techniques along with research guidelines and overviews of key topics. It is the hope of IUPHAR/BPS Guide to PHARMACOLOGY to be useful for researchers and students in pharmacology and drug discovery and provide the general public with accurate information on the basic science underlying drug action.

The information provided in this dataset shows the initial view or landing pages for each target family that provides expert-curated overviews of the key properties and selective ligands and tool compounds available. Additional information can be found also in other databases including Ensembl, UniProt, PubChem, ChEMBL, and DrugBank, as well as curated chemical information and literature citations in PubMed.

In this dataset, the target class or “target” refers to a record in the database that has been resolved to a UniProtKB/SwissProt ID as the primary identifier. Target class content includes the following 7TM receptors, Nuclear hormone receptors, Catalytic receptors, Ligand-gated ion channels, Voltage-gated ion channels, Other ion channels, Enzymes (all), Transporters, Kinases, Proteases and Other proteins. Note that not all 7TM receptor records are unequivocally assigned as GPCRs, but for convenience, they are referred to generally as GPCRs or G protein-coupled receptors in the study.

As stated in the study, the term “target” in the database also includes verified targets for the MMOAs for drugs used to treat human diseases, newer receptor-ligand pairings judged to be credible by a dedicated NC-IUPHAR subcommittee, and human targets identified by the orthologue activity mapping where only non-human binding data are available. In addition, the database also contains the targets of undesirable ligand interactions known as anti-targets as well as emergent targets which are proteins that do not have sufficient validation data to be considered bonafide therapeutic drug targets but are nonetheless being investigated to both establish their normal function and possible disease involvement.

This updated database enables a more detailed exploration of statistics as it provides a detailed overview of the database and allows comparison with other resources, communication of results to users and funders, measures progress and identifies areas for expansion.

Date Created

2011

Last Modified

2017-04-24

Version

2017.3

Update Frequency

Quarterly

Temporal Coverage

N/A

Spatial Coverage

N/A

Source

John Snow Labs => International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS) Guide to PHARMACOLOGY

Source License URL

John Snow Labs Standard License

Source License Requirements

N/A

Source Citation

Southan C, Sharman JL, Benson HE, Faccenda E, Pawson AJ, Alexander SPH, Buneman OP, Davenport AP, McGrath JC, Peters JA, Spedding M, Catterall WA, Fabbro D, Davies JA; NC-IUPHAR. (2016) The IUPHAR/BPS Guide to PHARMACOLOGY in 2016 towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucl. Acids Res. 44 (Database Issue) D1054-68

Keywords

Targeted Therapy, Target Sheets, Molecular Targeted Therapy, Drug Molecules

Other Titles

Pharmacology Targeted Therapy and Family List Identification, Pharmacology Complete Target Sheets and Family List Identification, Pharmacology Molecular Targeted Therapy

Name Description Type Constraints
Type_or_Target_ClassThe target class or “target” refers to a record in the database that has been resolved to a UniProtKB/SwissProt ID as the primary identifier. Target class content includes the following 7TM receptors, Nuclear hormone receptors, Catalytic receptors, Ligand-gated ion channels, Voltage-gated ion channels, Other ion channels, Enzymes (all), Transporters, Kinases, Proteases and Other proteins. Not all 7TM receptor records are unequivocally assigned as GPCRs, but for convenience, they are referred to generally as GPCRs or G protein-coupled receptors in the database.stringrequired : 1
Family_IdThe Guide to Pharmacology (GtP) family identifierintegerrequired : 1 level : Nominal
Family_NameThe Guide to Pharmacology (GtP) family namestringrequired : 1
Target_IdThe Guide to Pharmacology (GtP) target identifierintegerrequired : 1 level : Nominal
Target_NameThe Guide to Pharmacology (GtP) target name, usually the IUPHAR recommended name or a provisional name (for information on target nomenclature see the online help documentation)stringrequired : 1
SubunitsThe names of any subunits that make up a multimeric proteinstring-
Target_Systematic_NameA systematic name associated with the targetstring-
Target_Abbreviated_NameA commonly used abbreviation of the target namestring-
SynonymsOther names commonly used in the literaturestring-
HUGO_Gene_Nomenclature_Committee_IdThe HUGO Gene Nomenclature Committee (HGNC) gene identifierstring-
HUGO_Gene_Nomenclature_Committee_SymbolThe HGNC gene symbolstring-
HUGO_Gene_Nomenclature_Committee_NameThe HGNC gene namestring-
Human_Genetic_LocalisationThe genetic location of the encoding gene in humanstring-
Human_Nucleotide_RefSeqThe RefSeq identifier for the human mRNA sequencestring-
Human_Protein_RefSeqThe RefSeq identifier for the human protein sequencestring-
Human_SwissProtThe UniProtKB/SwissProt Accession for the human protein sequencestring-
Human_Entrez_GeneThe human Entrez Gene identifierstring-
Rat_Genome_Database_IdThe Rat Genome Database (RGD) gene identifierstring-
Rat_Genome_Database_SymbolThe RGD gene symbolstring-
Rat_Genome_Database_NameThe RGD gene namestring-
Rat_Genetic_LocalisationThe genetic location of the encoding gene in ratstring-
Rat_Nucleotide_RefSeqThe RefSeq identifier for the rat mRNA sequencestring-
Rat_Protein_RefSeqThe RefSeq identifier for the rat protein sequencestring-
Rat_SwissProtThe UniProtKB/SwissProt Accession for the rat protein sequencestring-
Rat_Entrez_GeneThe rat Entrez Gene identifierstring-
Mouse_Genome_Informatics_IdThe Mouse Genome Informatics (MGI) gene identifierstring-
Mouse_Genome_Informatics_SymbolThe MGI gene symbolstring-
Mouse_Genome_Informatics_NameThe MGI gene namestring-
Mouse_Genetic_LocalisationThe genetic location of the encoding gene in mousestring-
Mouse_Nucleotide_RefSeqThe RefSeq identifier for the mouse mRNA sequencestring-
Mouse_Protein_RefSeqThe RefSeq identifier for the mouse protein sequencestring-
Mouse_SwissProtThe UniProtKB/SwissProt Accession for the mouse protein sequencestring-
Mouse_Entrez_GeneThe mouse Entrez Gene identifierstring-
Type_or_Target_ClassFamily_IdFamily_NameTarget_IdTarget_NameSubunitsTarget_Systematic_NameTarget_Abbreviated_NameSynonymsHUGO_Gene_Nomenclature_Committee_IdHUGO_Gene_Nomenclature_Committee_SymbolHUGO_Gene_Nomenclature_Committee_NameHuman_Genetic_LocalisationHuman_Nucleotide_RefSeqHuman_Protein_RefSeqHuman_SwissProtHuman_Entrez_GeneRat_Genome_Database_IdRat_Genome_Database_SymbolRat_Genome_Database_NameRat_Genetic_LocalisationRat_Nucleotide_RefSeqRat_Protein_RefSeqRat_SwissProtRat_Entrez_GeneMouse_Genome_Informatics_IdMouse_Genome_Informatics_SymbolMouse_Genome_Informatics_NameMouse_Genetic_LocalisationMouse_Nucleotide_RefSeqMouse_Protein_RefSeqMouse_SwissProtMouse_Entrez_Gene
other_protein785Sigma receptors2553σ2
lgic73Glycine receptors428Glycine Receptor (All subtypes)
lgic685-HT<sub>3</sub> receptors3795-HT<sub>3</sub>A5-HT3A
enzyme565Casein kinase 2 (CK2) family1548Casein kinase 2CK2
enzyme562CAMK2 family1554Calmodulin-dependent kinase IICaMKII
other_ic119Aquaporins697AQP1016029AQP10aquaporin 101q21.3Q96PS889872
gpcr11Calcitonin receptors45AMY<sub>2</sub> receptorRAMP2|CT receptor
gpcr11Calcitonin receptors46AMY<sub>3</sub> receptorRAMP3|CT receptor
enzyme474AMPK subfamily1540AMP kinaseAMPKAMP-activated protein kinase
gpcr11Calcitonin receptors44AMY<sub>1</sub> receptorRAMP1|CT receptorCTR/RAMP1