Others titles

  • Pharmacology Gene Sequencing Data
  • Pharmacology Genome Sequencing Data
  • Pharmacology Interaction Data for Molecular Model

Keywords

  • Gene Sequencing
  • Genome Sequencing
  • DNA Sequencing
  • Molecular Model

Pharmacology Interaction Data for Targets and Ligands

This dataset shows the Interaction Data for Targets and Ligands from the Guide to PHARMACOLOGY; an online, open-access portal to pharmacological information on all the human targets of prescription drugs, which is the product from the collaboration of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS).

Log in to download
Complexity

Get The Data

For getting access to data download links please read and accept the end-user license agreement.
Your Data License
  • Research
    Non-Commercial, Share-Alike, Attribution Free Forever
  • Commercial
    Commercial Use, Remix & Adapt, White Label Log in to download

John Snow Labs Standard End User License Agreement

Last updated:January 20, 2021

This Standard End User License Agreement (“EULA”) applies to customers of John Snow Labs Inc. (as defined below), using any product of John Snow Labs Inc. on John Snow Labs Marketplace as defined below (hereinafter referred to “you”) and John Snow Labs Inc., a Delaware corporation (“John Snow Labs”, “we” or “us”).

By downloading, installing, and/or using (as applicable) any Product of John Snow Labs (as defined below), you automatically agree to be bound by, and use our Products in compliance with, this EULA. This EULA, together with additional terms and conditions and/or policies referenced herein or located on https://www.johnsnowlabs.com and/or conveyed to you by John Snow Labs, is a legally binding contract between you and John Snow Labs.

PLEASE READ THIS EULA CAREFULLY BEFORE PURCHASING, INSTALLING OR USING OUR PRODUCTS MADE AVAILABLE ON JOHN SNOW LABS MARKETPLACE.

We may make changes to this EULA from time to time. When we do so, we will revise the “last updated” date given above. The then-current version of this EULA will supersede all earlier versions. You agree that your continued use of our Products after such changes have been published to our EULA will constitute your acceptance of such revised EULA.

Definitions

“John Snow Labs Data Library” means a data library located at https://www.johnsnowlabs.com;

“Products” means products and services of John Snow Labs that you download and use from listings in John Snow Labs Data Library;

Important Notice

By installing and using our Products, you acknowledge that the use of the Products can be subject to the restrictions and controls imposed by United States export regulations.

You represent and warrant that you do not intend to use the Products for any purpose prohibited by United States export regulations, including, without limitation, terrorism, cyber-attacks, cyber-crimes, money-laundering, industrial espionage, or nuclear, chemical or biological weapons proliferation. Further, you represent and warrant that you are not listed as a denied party on any list governing United States exports.

Eligibility

Our Products can be used by an individual, business or other legal entity, or both. If you are entering into this EULA, or using the Products, on behalf of a company or other legal entity, you represent that you have the authority to bind such entity to this EULA, in which case “you” shall refer to such entity.

In the event you have entered into a separate written agreement with John Snow Labs regarding the Products that contemplates terms that are inconsistent with this EULA, the written agreement shall control and this EULA will not apply to you to the extent inconsistent with such written agreement, or, if such written agreement is contemplated to be in lieu of this EULA, then this EULA shall not apply at all.

Your Access and Use

Subject to your compliance with this EULA, as well as any other applicable policies, John Snow Labs grants you non-exclusive, non-transferable, license to install, access to, modify, and use of, the Products worldwide (subject to applicable export laws) during the term of this EULA (as described below) solely for research, private study and personal use of Products.

This license is personal to you, and you may not resell our Products, permit other users access to our Products through your account. Your right to use our Products is limited by all terms and conditions set forth in this EULA.

Except for your pre-existing rights and this license granted to you, we and our licensors retain all rights, titles and interests in and to our Products, all related intellectual property rights, including trademarks (whether registered or pending), domain and business names. Our Products are protected by applicable intellectual property laws, including United States copyright law and international treaties.

Except for the foregoing license, you have no other rights in the Products and you may not modify, edit, copy, reproduce, create derivative works of, reverse engineer, alter, enhance or in any way exploit the Products in any manner. If you breach any of this EULA, the above license will terminate automatically.

You will be deemed to have taken any action that you permit, assist or facilitate any person or entity to take related to this EULA, your content or use of the Products. You are responsible for end users’ use of your content and the Products. You will ensure that all end users comply with your obligations under this EULA and that the terms of your agreement with each end user are consistent with this EULA. If you become aware of any violation of your obligations under this EULA caused by an end user, you will immediately suspend access to your content and the Products by such end user. We do not provide any support or services to end users unless we have a separate agreement with you or an end user obligating us to provide such support or services.

Restrictions

You will access or use our Products solely via John Snow Labs Data Library.

Except as otherwise explicitly provided in this EULA or as may be expressly permitted by applicable law, you will not, and will not permit or authorize any third party to:

  1. reproduce, modify, translate, enhance, decompile, disassemble, reverse engineer or create derivative works of any of our Products or its technological features or measures;
  2. rent, lease, sell, resell, loan, distribute, or sublicense access to any of our Products;
  3. circumvent or disable any security or technological features or measures of our Products;
  4. use our intellectual property rights without our express prior written authorization;
  5. use our Products for more than one trial period, unless the trial period is extended by John Snow Labs’ prior written permit;
  6. use our Products with an intent to build a competitive product or service, or copy or substantially copy any ideas, features, functions, organization, structure, application program interface, graphics, or user interface of the Products;
  7. store, copy, modify, distribute, or resell any of the information; audio, visual, and audiovisual works, or other content made available on our Products (collectively, “Content”) or compile or collect any Content as part of a database or other work;
  8. use any automated tool (e.g., robots, spiders) to access or use our Products, or to store, copy, modify, distribute, or resell any Content;
  9. circumvent or disable any rights management, usage rules, or other security features of our Products;
  10. use our Products in a manner that overburdens, or that threatens the integrity, performance, or availability of, our Products; or
  11. remove, alter, or obscure any proprietary notices (including copyright and trademark notices) on any portion of our Products or any Content.

Fees and Taxes

Your use of the Products is subject to our fees. All fees are given on our website https://www.johnsnowlabs.com. Except as set forth in this EULA, the fees are non-refundable. We are entitled to revise our fees from time to time.

The fees exclude any federal, state or local taxes, VAT, GST, or similar taxes. You are responsible for identification and payment of all taxes as required by applicable law.

Term and Termination

This EULA will become effective as of the date of your order of Products and shall be in effect until terminated.

John Snow Labs may suspend or terminate your right to use our Products, if you or your end user’s use of the Products:

  1. is in breach of this EULA;
  2. poses a security risk to our Products;
  3. could adversely impact our systems, the Products or other customers;
  4. could subject us, our affiliates, or any third party to liability; or
  5. could be fraudulent.

We may also suspend or terminate your right to use our Products, if you fail to perform your payment obligations, or you have ceased to operate in the ordinary course, made an assignment for the benefit of creditors or similar disposition of your assets, or become the subject of any bankruptcy, reorganization, liquidation, dissolution or similar proceeding.

We may also suspend or terminate your right to use our Products without any reason upon a relevant 30 days’ written notice to you and will refund the unused fees pre-paid by you for access to the Products for the affected time period (if any). Where your access is suspended or terminated by the breach of this EULA or applicable laws, John Snow Labs will will not provide, or be liable for, any refund.

You will cease use of the Products during any period of suspension, or upon termination of this EULA.

All provisions which by their nature are intended to survive termination shall survive termination of this EULA.

Support

If applicable to your Product, John Snow Labs will provide you with the support services. If you use a trial access, support services are excluded. Under this EULA, our support services exclude any installation, training, maintenance services (including any error corrections, bug fixes, or new releases), technical assistance, consulting services, or other services of any kind. Such services are provided at John Snow Labs’ discretion.

From time to time John Snow Labs can perform updates to our software. If available, such updates may include bug fixes, new features and/or enhancements. You are solely responsible for deploying such updates at your own risk and liability.

Access to our Products

We do not provide you with the equipment to access our Products. You are responsible for all fees charged by third parties related to your access and use of our Products (e.g., charges by Internet service providers).

You are responsible for monitoring your use of the Products, including payment of all fees and/or taxes related to such access and use. You agree that John Snow Labs is permitted to request and you hereby consent to provide John Snow Labs information related to your use of the Products for auditing purposes.

You also certify that you are legally permitted to use the Products, and take full responsibility for the selection and use of the Products. This EULA is void where prohibited by law, and the right to use the Products is revoked in such jurisdictions. John Snow Labs makes no claim that the Products may be lawfully used outside of the United States. If you use the Products from outside of the United States, you do so at your own risk and you are responsible for compliance with the laws of jurisdiction.

Privacy Policy

We may collect, store and receive personal and other information about you through our Products. Our collection and use of this information is governed by our Privacy Policy available at https://www.JohnSnowLabs.com/privacy/ which may be amended from time to time.

Links and Third Party Content

Our Products may display, or contain links to, third party products, services, and websites. Any opinions, advice, statements, services, offers, or other information that constitutes part of the content expressed, authored, or made available by other users or other third parties, or which is accessible through or may be located using our Products (collectively, “Third Party Content”) are those of the respective authors or producers and not of us or our shareholders, directors, officers, employees, agents, or representatives.

We do not control Third Party Content and do not guarantee the accuracy, integrity or quality of such Third Party Content. We are not responsible for the performance of, we do not endorse, and we are not responsible or liable for, any Third Party Content or any information or materials advertised in any Third Party Content. By using our Products, you may be exposed to content that is offensive, indecent, or objectionable. We are not responsible or liable, directly or indirectly, for any damage or loss caused to you by your use of or reliance on any goods, services, or information available on or through any third party service or Third Party Content. It is your responsibility to evaluate the information, opinion, advice, or other content available on and through our Products.

Proprietary Rights

John Snow Labs will not obtain any rights under this EULA from you (or your licensors) to your content.

The Products, including software, is and remains the exclusive property of John Snow Labs and its licensors. Except for the access and use rights expressly set forth in this EULA, no license or other rights in or to the Products or John Snow Labs trademark(s) and other intellectual property rights therein, are granted to you, and all such licenses and rights are expressly reserved. You will not remove, alter, or obscure any proprietary notices (including copyright and trademark notices) on any portion of our Products or any Content.

Trademarks

“John Snow Labs,” the John Snow Labs logo, and any other product, business or service name or slogan, whether registered or pending, displayed on our Products are trademarks of John Snow Labs, Inc. or its suppliers or licensors, and may not be copied, imitated or used, in whole or in part, without the prior written permission of John Snow Labs or the applicable trademark holder. You may not use any metatags or any other “hidden text” utilizing “John Snow Labs” or any other name, trademark or product, business or service name of John Snow Labs without our prior written permission. In addition, the look and feel of our Products, including all page headers, custom graphics, button icons and scripts, is the service mark, trademark and/or trade dress of John Snow Labs and may not be copied, imitated or used, in whole or in part, without our prior written permission. All other trademarks, pending trademarks, registered trademarks, product names and company names or logos mentioned in our Products are the property of John Snow Labs Inc. and/or their respective owners. Reference to any products, services, processes or other information, by trade name, trademark, manufacturer, supplier, or otherwise does not constitute or imply endorsement, sponsorship, or recommendation thereof by us.

Disclaimer of Warranties

YOUR USE OF THE PRODUCTS IS AT YOUR SOLE RISK. THE PRODUCTS AND CONTENT EACH ARE PROVIDED ON AN “AS IS” AND “AS AVAILABLE” BASIS. WE AND OUR SUPPLIERS AND LICENSORS EXPRESSLY DISCLAIM ALL WARRANTIES OF ANY KIND, WHETHER EXPRESS OR IMPLIED, INCLUDING, BUT NOT LIMITED TO THE IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, TITLE, AND NON-INFRINGEMENT. WE DO NOT GUARANTEE THE ACCURACY, COMPLETENESS, OR USEFULNESS OF THE PRODUCTS OR ANY CONTENT, AND YOU RELY ON THE PRODUCTS AND CONTENT AT YOUR OWN RISK. ANY MATERIAL THAT YOU ACCESS OR OBTAIN THROUGH OUR PRODUCTS IS DONE AT YOUR OWN DISCRETION AND RISK AND YOU WILL BE SOLELY RESPONSIBLE FOR ANY DAMAGE TO YOUR COMPUTER OR LOSS OF DATA THAT RESULTS FROM THE DOWNLOAD OF ANY MATERIAL THROUGH OUR PRODUCTS. NO ADVICE OR INFORMATION, WHETHER ORAL OR WRITTEN, OBTAINED BY YOU FROM US OR THROUGH OR FROM OUR PRODUCTS WILL CREATE ANY WARRANTY NOT EXPRESSLY STATED IN THIS EULA. SOME STATES MAY PROHIBIT A DISCLAIMER OF WARRANTIES AND YOU MAY HAVE OTHER RIGHTS THAT VARY FROM STATE TO STATE.

Limitation of Liability

WE AND OUR SUPPLIERS AND LICENSORS WILL NOT BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, CONSEQUENTIAL, OR EXEMPLARY DAMAGES, INCLUDING BUT NOT LIMITED TO, DAMAGES FOR LOSS OF PROFITS, GOODWILL, USE, DATA, OR OTHER INTANGIBLE LOSSES (EVEN IF WE HAVE BEEN ADVISED OF THE POSSIBILITY OF THESE DAMAGES), RESULTING FROM YOUR USE OF OUR PRODUCTS AND CONTENT. UNDER NO CIRCUMSTANCES WILL THE TOTAL LIABILITY OF US AND OUR SUPPLIERS AND LICENSORS OF ALL KINDS ARISING OUT OF OR RELATED TO YOUR USE OF THE PRODUCTS AND CONTENT (INCLUDING BUT NOT LIMITED TO WARRANTY CLAIMS), REGARDLESS OF THE FORUM AND REGARDLESS OF WHETHER ANY ACTION OR CLAIM IS BASED ON CONTRACT, TORT, OR OTHERWISE, EXCEED THE AMOUNTS, IF ANY, THAT YOU HAVE PAID FOR YOUR USE OF THE PRODUCTS AND CONTENT. BECAUSE SOME STATES DO NOT ALLOW THE EXCLUSION OR LIMITATION OF LIABILITY FOR CONSEQUENTIAL OR INCIDENTAL DAMAGES, THE ABOVE LIMITATION MAY NOT APPLY TO YOU.

Indemnity

To the full extent permitted by applicable law, you shall defend, indemnify and hold harmless John Snow Labs, its affiliates and its licensors, and each of their respective employees, officers, directors, and representatives from and against any claims, damages, losses, liabilities, costs, and expenses (including reasonable attorney’s fees) arising out of or relating to any third party claim concerning: (a) your use of the Products; (b) breach of this EULA or violation of applicable law by you; (c) any content or the combination of such content with other software, content or processes, including any claim involving alleged infringement or misappropriation of third-party rights by such content or combination; or (d) breach of any obligation or duty you owe to a third party.

Legal Notices

Enforcement of this EULA will be governed by the laws of the State of Delaware, excluding its conflict and choice of law principles. The exclusive jurisdiction and venue for any claims arising out of or related to this EULA or your use of the Products will lie in the state and federal courts located in Sussex County, within the State of Delaware, and you irrevocably agree to submit to the jurisdiction of such courts. Our failure to enforce any right or provision in this EULA will not constitute a waiver of such right or provision unless acknowledged and agreed by us in writing. In the event that a court of competent jurisdiction finds any provision of this EULA to be illegal, invalid, or unenforceable, the remaining provisions will remain in full force and effect.

Notifications

We may use your contact information to notify you if we have any legitimate interest or if we need to notify you on any important information related to your use of Products. We will not send you newsletters unless you expressly consented to such notifications.

Contacting Us

If you have any questions or concerns about our Products or this EULA, you may contact us by email at support@JohnSnowLabs.com.

Description

The data types captured in this dataset include target nomenclature, pharmacological data, and ligand structures. Organisms isolated in this data are from human, mouse, and rat.

In future versions, the plan is to add resources for education and training in pharmacological principles and techniques along with research guidelines and overviews of key topics. It is the hope of IUPHAR/BPS Guide to PHARMACOLOGY to be useful for researchers and students in pharmacology and drug discovery and provide the general public with accurate information on the basic science underlying drug action.

The information provided in this dataset shows the initial view or landing pages for each target family that provides expert-curated overviews of the key properties and selective ligands and tool compounds available. Additional information can be found also in other databases including Ensembl, UniProt, PubChem, ChEMBL, and DrugBank, as well as curated chemical information and literature citations in PubMed.

This dataset contains quantitative ligand-to-protein interaction mappings. Relationship data across all targets and interaction type include targets with ligand interactions, targets with quantitative ligand interactions, targets with approved drug interactions, primary targets with approved interactions, ligand with target interactions, ligands with quantitative interactions (approved drugs), ligands with clinical use summaries (approved drugs), number of binding constants and number of binding constants curated from literature.

About this Dataset

Data Info

Date Created

2011

Last Modified

2022-06-09

Version

2022.2

Update Frequency

Quarterly

Temporal Coverage

N/A

Spatial Coverage

N/A

Source

John Snow Labs; International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS) Guide to PHARMACOLOGY;

Source License URL

Source License Requirements

N/A

Source Citation

N/A

Keywords

Gene Sequencing, Genome Sequencing, DNA Sequencing, Molecular Model

Other Titles

Pharmacology Gene Sequencing Data, Pharmacology Genome Sequencing Data, Pharmacology Interaction Data for Molecular Model

Data Fields

Name Description Type Constraints
Target_NameThe GtP target name (for information on target nomenclature see the online help documentation)string-
Target_IdThe GtP target identifierintegerlevel : Nominal
Target_Gene_SymbolThe target gene symbolstring-
Target_UniprotThe target's UniProtKB accessionstring-
Target_Ensembl_Gene_IdA target identifier listed as an Ensembl gene ID.string-
Target_LigandThe name of a GtP ligand which in this case is actually the target of the interactionstring-
Target_Ligand_IdThe identifier of the ligand which in this case is the target of the interactionintegerlevel : Nominal
Target_Ligand_Gene_SymbolThe gene symbol of the target ligand (for peptides)string-
Target_Ligand_Ensembl_Gene_IdA target ligand identifier listed as an Ensembl gene ID.string-
Target_Ligand_UniprotThe target ligand's UniProtKB accession (if endogenous peptide)string-
Target_Ligand_Pubchem_Substance_IdThe target ligand's PubChem Substance IDstring-
Target_SpeciesThe name of the target speciesstringrequired : 1
Ligand_NameThe name of the GtP (Guanosine-5'-triphosphate) ligandstringrequired : 1
Ligand_IdThe GtP(Guanosine-5'-triphosphate) ligand identifierintegerlevel : Nominalrequired : 1
Ligand_Gene_SymbolThe ligand gene symbol (if endogenous peptide)string-
Ligand_SpeciesThe name of the ligand species (if peptide)string-
Ligand_Pubchem_Substance_IdThe ligand's PubChem Substance IDstring-
Is_Approved_DrugThe drug is or has in the past been approved for human clinical use by a regulatory agency.boolean-
Interaction_TypeType of interactionstringrequired : 1
Ligand_ActionSpecific action of the ligandstringrequired : 1
Action_CommentFurther details or qualifiers for the ligand action at the targetstring-
SelectivitySelectivity whether selective, non-selective, family selective or nonestring-
Is_EndogenousTrue if the ligand is endogenous in the target organism under studybooleanrequired : 1
Is_Primary_TargetTrue if the target can be considered the primary target of the ligandboolean-
Concentration_RangeThe micromolar concentration range of ligand used in the study (primarily given when affinity data are not available)string-
Affinity_UnitsThe negative logarithm to base 10 of the experimental parameter measuredstring-
Affinity_HighIf there is a range of activity values, this would be the highest negative logarithm to base 10 valuenumberlevel : Ratio
Affinity_MedianThis is either the median or a single negative logarithm to base 10 affinity valuenumberlevel : Ratio
Affinity_LowIf there is a range of activity values, this would be the lowest negative logarithm to base 10 valuenumberlevel : Ratio
Original_Affinity_UnitsThe experimental parameter measured in the study e.g. IC50string-
Original_Affinity_Low_NmThe lowest nM activity value recorded in the studynumberlevel : Ratio
Original_Affinity_Median_NmEither the median or a single nM activity valuenumberlevel : Ratio
Original_Affinity_High_NmThe greatest nM activity value recorded in the studynumberlevel : Ratio
Original_Affinity_RelationA qualifier for the activity value, e.g. Equal, Less than or Greater thanstring-
Assay_DescriptionFurther details captured about the assaystring-
Receptor_SiteA specific binding site on the target to which the ligand bindsstring-
Ligand_ContextIf the ligand is context-dependent e.g. intracellular, this is indicatedstring-
Pubmed_IdPubMed ids for cited publicationsstring-

Data Preview

Target NameTarget IdTarget Gene SymbolTarget UniprotTarget Ensembl Gene IdTarget LigandTarget Ligand IdTarget Ligand Gene SymbolTarget Ligand Ensembl Gene IdTarget Ligand UniprotTarget Ligand Pubchem Substance IdTarget SpeciesLigand NameLigand IdLigand Gene SymbolLigand SpeciesLigand Pubchem Substance IdIs Approved DrugInteraction TypeLigand ActionAction CommentSelectivityIs EndogenousIs Primary TargetConcentration RangeAffinity UnitsAffinity HighAffinity MedianAffinity LowOriginal Affinity UnitsOriginal Affinity Low NmOriginal Affinity Median NmOriginal Affinity High NmOriginal Affinity RelationAssay DescriptionReceptor SiteLigand ContextPubmed Id
12S-LOX1387ALOX12P18054ENSG0000010883900HumanML3558752252827410FalseInhibitorInhibitionSelectiveFalseTruepIC5006.469999790IC5003400=24393039
15-LOX-11388ALOX15P16050ENSG0000016190500HumanPKUMDL_MH_10019141315661226FalseAllosteric modulatorPositiveNot DeterminedFalseFalsepKd05.4099998470000010Kd039000=Determined by surface plasmon resonance (SPR)26290290
15-LOX-11388ALOX15P16050ENSG0000016190500Humancompound 34 [PMID: 20866075]8751252827409FalseInhibitorInhibitionSelectiveFalseTruepKi08.00Ki0100<20866075
15-LOX-11388ALOX15P16050ENSG0000016190500HumanML35110263381744944FalseInhibitorInhibitionNot DeterminedFalseFalsepIC5006.69999980899999950IC5002000=24672829
15-LOX-11388ALOX15P16050ENSG0000016190500HumanPD-14617611390440816759FalseInhibitorInhibitionNot DeterminedFalseFalsepKi06.69999980899999950-000=9105693
15-LOX-21389ALOX15BO15296ENSG0000017959300Humancompound 21n [PMID: 17656086]8750252827408FalseInhibitorInhibitionNot DeterminedFalseFalsepIC5007.28999996200000040IC500510=17656086
15-LOX-21389ALOX15BO15296ENSG0000017959300HumanMLS00053692410264381744945FalseInhibitorInhibitionNot DeterminedFalseFalsepKi05.5999999050Ki025000=25111178
3-Mercaptopyruvate sulfurtransferase1446MPSTP25325ENSG0000012830900HumanI3MT-310210381744892FalseInhibitorInhibitionNot DeterminedFalseFalsepIC5005.5700001720IC50027000=28079151
3-phosphoinositide dependent protein kinase 11519PDPK1O15530ENSG0000014099200Human7-hydroxystaurosporine7907249565590FalseInhibitorInhibitionNot DeterminedFalseTruepIC5007.4800000189999990IC500330=11896604
3-phosphoinositide dependent protein kinase 11519PDPK1O15530ENSG0000014099200HumanBX-7958006249565686FalseInhibitorInhibitionNot DeterminedFalseTruepIC5007.96000003799999960IC500110=In a direct kinase activity measuring phosphorylation od a small peptide substrate mimetic15772071