Pharmacology Mapping of Target and HGNC ID and Symbols

$179 / year

This dataset shows the Target Identification and HGNC ID and Symbols from the Guide to PHARMACOLOGY; an online, open-access portal to pharmacological information on all the human targets of prescription drugs, which is the product from the collaboration of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS).

Complexity

The data types captured in this dataset include target nomenclature, pharmacological data, and ligand structures. Organisms isolated in this data are from human, mouse, and rat.

In future versions, the plan is to add resources for education and training in pharmacological principles and techniques along with research guidelines and overviews of key topics. It is the hope of IUPHAR/BPS Guide to PHARMACOLOGY to be useful for researchers and students in pharmacology and drug discovery and provide the general public with accurate information on the basic science underlying drug action.

The information provided in this dataset shows the initial view or landing pages for each target family that provides expert-curated overviews of the key properties and selective ligands and tool compounds available. Additional information can be found also in other databases including Ensembl, UniProt, PubChem, ChEMBL, and DrugBank, as well as curated chemical information and literature citations in PubMed.

Families and groups of genes related by sequence and/or function are named using a “root” symbol. This is an efficient and informative way to name related genes and already works well for a number of established gene families.

Date Created

2011

Last Modified

2020-03-12

Version

2020.2

Update Frequency

Quarterly

Temporal Coverage

N/A

Spatial Coverage

N/A

Source

John Snow Labs; International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS) Guide to PHARMACOLOGY;

Source License URL

Source License Requirements

N/A

Source Citation

Southan C, Sharman JL, Benson HE, Faccenda E, Pawson AJ, Alexander SPH, Buneman OP, Davenport AP, McGrath JC, Peters JA, Spedding M, Catterall WA, Fabbro D, Davies JA; NC-IUPHAR. (2016) The IUPHAR/BPS Guide to PHARMACOLOGY in 2016 towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucl. Acids Res. 44 (Database Issue) D1054-68

Keywords

Genome, National Center for Biotechnology Information, NCBI Nucleotide, Genome Sequencing, NCBI Database, Gene ID, Genome Database

Other Titles

Pharmacology Genome Target Identification and HGNC ID and Symbols, Pharmacology Genome Sequencing and HGNC ID and Symbols, Pharmacology Gene ID and HGNC ID and Symbols, Pharmacology Genome Database and HGNC ID and Symbols

NameDescriptionTypeConstraints
HUGO_Gene_Nomenclature_Committee_SymbolThe Human Genome Organization (HUGO) Gene Nomenclature Committee (HGNC) gene symbolstringrequired : 1
HUGO_Gene_Nomenclature_Committee_IdThe Human Genome Organization (HUGO) Gene Nomenclature Committee (HGNC) gene identifierintegerlevel : Nominal
IUPHAR_NameThe GtP target name, usually the International Union of Basic and Clinical Pharmacology (IUPHAR) recommended a name or a provisional name (for information on target nomenclature see the online help documentation)stringrequired : 1
IUPHAR_IdThe GtP International Union of Basic and Clinical Pharmacology (IUPHAR) target identifierintegerlevel : Nominal required : 1
GTP_UrlThe GtP (guanosine triphosphate) target page URLstringrequired : 1
HUGO Gene Nomenclature Committee SymbolHUGO Gene Nomenclature Committee IdIUPHAR NameIUPHAR IdGTP Url
AAK119679AP2 associated kinase 11921http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1921
AATK21apoptosis associated tyrosine kinase1922http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1922
ABAT234-aminobutyrate aminotransferase2464http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2464
ABCA129ABCA1756http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=756
ABCA1030ABCA10765http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=765
ABCA1214637ABCA12766http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=766
ABCA1314638ABCA13767http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=767
ABCA232ABCA2757http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=757
ABCA333ABCA3758http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=758
ABCA434ABCA4759http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=759