Chemical Gene Interaction Types

$79 / year

This dataset contains the terms of the vocabulary used in the Comparative Toxicogenomics Database (CTD) to describe the type of relationship inferred between the chemical and the gene, these terms define different effects of the chemical over the gene or the products of a gene at a molecular level. The vocabulary used in the CTD is organized in a hierarchical manner, for which many of the terms have a parent term and at the same time could have a descendant term. This dataset is part of the CTD and can be better understood and used along with the other datasets that belong to the CTD.


The Comparative Toxicogenomics Database (CTD) purpose is to provide a tool to generate new hypotheses on the mechanism of chemicals in the development of diseases by collecting curated data reported in the scientific literature on chemicals, genes and diseases and making inferences on the relationships of these three elements.

The CTD datasets can be used to create a tool for input of queries to obtain inferred relationships between genes, chemicals and diseases and the significance of the inferences. When a query is run, the terms on this dataset are used in the result to describe the action of a chemical over a respective gene.

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John Snow Labs => Comparative Toxicogenomics Database

Source License URL

John Snow Labs Standard License

Source License Requirements

Publicly available and free for research application but citation is required. Permission asked for commercial uses

Source Citation

Davis AP, Grondin CJ, Johnson RJ, Sciaky D, King BL, McMorran R, Wiegers J, Wiegers TC, Mattingly CJ. The Comparative Toxicogenomics Database update 2017. Nucleic Acids Res. 2016 Sep 19;[Epub ahead of print]


Toxicogenomics, CTD Vocabulary, Gene Parent Terms, Gene Descendant Terms, Mechanism of Disease Development, Relationship Between Genes, Comparative Toxicogenomics Database, Relationships Between Chemicals and Diseases, Chemical and Disease Inferences, Chemical Disease Hypotheses

Other Titles

Type of Relationship Between Genes and Chemicals, Biological Process Involved in Associations Genes Chemicals, Nomenclature of Biological Process, Chemical Gene Interaction Types Phenotypic Ratio, Chemical Gene Interaction Types Epistasis, Chemical Gene Interaction Types Phenotypic Ratio

Name Description Type Constraints
Interaction_Type_NameName of interaction (reaction) between the chemical and the gene (or between the chemical and proteins). These interactions are from published references in vertebrates and invertebrates.stringrequired : 1
CodeAbbreviation of the interaction.stringrequired : 1
DescriptionDefinition of the interaction.stringrequired : 1
Parent_CodeParent interaction. Code of the reaction from which the listed interaction originates.string-
bindingbA molecular interaction.
oxidationoxdThe loss of electrons.met
reductionredThe gain of electrons.met
stabilitystaOverall molecular integrity.
degradationdegCatabolism or breakdown.met
acylationacyThe addition of an acyl group.met
expressionexpThe expression of a gene product.
aminationamiThe addition of an amine group.met
lipidationlipThe addition of a lipid group.met
sumoylationsumThe addition of a SUMO group.met