Others titles
- Type of Relationship Between Genes and Chemicals
- Biological Process Involved in Associations Genes Chemicals
- Nomenclature of Biological Process
- Chemical Gene Interaction Types Phenotypic Ratio
- Chemical Gene Interaction Types Epistasis
- Chemical Gene Interaction Types Phenotypic Ratio
Keywords
- Toxicogenomics
- CTD Vocabulary
- Gene Parent Terms
- Gene Descendant Terms
- Mechanism of Disease Development
- Relationship Between Genes
- Comparative Toxicogenomics Database
- Relationships Between Chemicals and Diseases
- Chemical and Disease Inferences
- Chemical Disease Hypotheses
Chemical Gene Interaction Types
This dataset contains the terms of the vocabulary used in the Comparative Toxicogenomics Database (CTD) to describe the type of relationship between the chemical and the gene, these terms define different effects of the chemical over the gene or the products of a gene at a molecular level. The vocabulary used in the CTD is organized in a hierarchical manner, for which many of the terms have a parent term and at the same time could have a descendant term.
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Description
The Comparative Toxicogenomics Database (CTD) purpose is to provide a tool to generate new hypotheses on the mechanism of chemicals in the development of diseases by collecting curated data reported in the scientific literature on chemicals, genes and diseases and making inferences on the relationships of these three elements.
The CTD datasets can be used to create a tool for input of queries to obtain inferred relationships between genes, chemicals and diseases and the significance of the inferences. When a query is run, the terms on this dataset are used in the result to describe the action of a chemical over a respective gene.
About this Dataset
Data Info
Date Created | 2004-01-20 |
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Last Modified | 2024-02-12 |
Version | 2024-02 |
Update Frequency |
Monthly |
Temporal Coverage |
N/A |
Spatial Coverage |
N/A |
Source | John Snow Labs; Comparative Toxicogenomics Database; |
Source License URL | |
Source License Requirements |
Publicly available and free for research application but citation is required. Permission asked for commercial uses |
Source Citation |
Publicly available and free for research application but citation is required. Permission asked for commercial uses |
Keywords | Toxicogenomics, CTD Vocabulary, Gene Parent Terms, Gene Descendant Terms, Mechanism of Disease Development, Relationship Between Genes, Comparative Toxicogenomics Database, Relationships Between Chemicals and Diseases, Chemical and Disease Inferences, Chemical Disease Hypotheses |
Other Titles | Type of Relationship Between Genes and Chemicals, Biological Process Involved in Associations Genes Chemicals, Nomenclature of Biological Process, Chemical Gene Interaction Types Phenotypic Ratio, Chemical Gene Interaction Types Epistasis, Chemical Gene Interaction Types Phenotypic Ratio |
Data Fields
Name | Description | Type | Constraints |
---|---|---|---|
Interaction_Type_Name | Name of interaction (reaction) between the chemical and the gene (or between the chemical and proteins). These interactions are from published references in vertebrates and invertebrates. | string | required : 1 |
Code | Abbreviation of the interaction. | string | required : 1 |
Description | Definition of the interaction. | string | required : 1 |
Parent_Code | Parent interaction. Code of the reaction from which the listed interaction originates. | string | - |
Data Preview
Interaction Type Name | Code | Description | Parent Code |
abundance | abu | The abundance of a chemical (if chemical synthesis is not known). | |
activity | act | An elemental function of a molecule. | |
binding | b | A molecular interaction. | |
cotreatment | w | Involving the use of two or more chemicals simultaneously. | |
expression | exp | The expression of a gene product. | |
folding | fol | The bending and positioning of a molecule to achieve conformational integrity. | |
localization | loc | Part of the cell where a molecule resides. | |
metabolic processing | met | The biochemical alteration of a molecule's structure (does not include changes in expression, stability, folding, localization, splicing, or transport). | |
acetylation | ace | The addition of an acetyl group. | met |
acylation | acy | The addition of an acyl group. | met |