Others titles
- Pathway Definitions
- Pathway Types Database
Keywords
- Toxicogenomics
- Gene Disease Association
- Gene Chemical Pathways
- Interaction Between Chemicals and Diseases
- KEGG and REACTOME Databases
- Comparative Toxicogenomics Database
- Relationships Between Chemicals and Diseases
- Chemical and Disease Inferences
- Chemical Disease Hypotheses
Chemical Pathway Vocabulary
This dataset contains the terms of the vocabulary used in the Comparative Toxicogenomics Database (CTD) to describe the biological or pathological process or reaction (pathway) involved in the interaction between a chemical and disease or gene. These pathways are identified through their codes in the KEGG and REACTOME databases. This dataset is part of the CTD and can be better understood and used along with the other datasets that belong to the CTD.
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Description
The Comparative Toxicogenomics Database (CTD) purpose is to provide a tool to generate new hypotheses on the mechanism of chemicals in the development of diseases by collecting curated data reported in the scientific literature on chemicals, genes and diseases, and making inferences on the relationships of these three elements.
The CTD datasets can be used to create a tool for input of queries to obtain inferred relationships between genes, chemicals and diseases and the significance of the inferences. When a query is run, the terms on this dataset are used in the result to describe the action of a chemical over a respective gene or disease.
About this Dataset
Data Info
Date Created | 2004-01-20 |
---|---|
Last Modified | 2024-05-30 |
Version | 2024-05 |
Update Frequency |
Monthly |
Temporal Coverage |
N/A |
Spatial Coverage |
N/A |
Source | John Snow Labs; Comparative Toxicogenomics Database; |
Source License URL | |
Source License Requirements |
Publicly available and free for research application but citation is required. Permission asked for commercial uses |
Source Citation |
Publicly available and free for research application but citation is required. Permission asked for commercial uses |
Keywords | Toxicogenomics, Gene Disease Association, Gene Chemical Pathways, Interaction Between Chemicals and Diseases, KEGG and REACTOME Databases, Comparative Toxicogenomics Database, Relationships Between Chemicals and Diseases, Chemical and Disease Inferences, Chemical Disease Hypotheses |
Other Titles | Pathway Definitions, Pathway Types Database |
Data Fields
Name | Description | Type | Constraints |
---|---|---|---|
Pathway_Name | Name of the pathway, which is a series of steps in biological processes at a molecular level that leads to a biological change; a pathway is possible due to the activities of multiple gene products and other elements. Pathways involve molecular interactions and reactions pertaining to metabolism, genetic information processing, environmental information processing, cellular processes, organismal systems, human diseases and drug development. Every pathway has a generic or standardized name that helps on obtaining an overview of the pathway’s nature, others have unique but well-known names, for example, the Krebs cycle. | string | required : 1 |
Pathway_ID | KEGG or REACTOME identifier. Alphanumerical code that identifies the pathway in the lookup of the KEGG or the REACTOME databases. KEGG Pathway Database is a collection of manually drawn pathway maps representing the knowledge on the molecular interaction and reaction networks for metabolism, genetic information processing, environmental information processing, cellular processes, organismal systems, human diseases and drug development. The Reactome Pathway Database is a curated database of pathways and reactions (pathway steps) in human biology. The Reactome definition of a 'reaction' includes many events in biology that change in state, such as binding, activation, translocation and degradation, in addition to classical biochemical reactions. Information in the database is authored by expert biologist researchers, maintained by Reactome editorial staff, and extensively cross-referenced to other resources e.g. NCBI, Ensembl, UniProt, UCSC Genome Browser, HapMap, KEGG (Gene and Compound), ChEBI, PubMed and GO. | string | required : 1 |
Data Preview
Pathway Name | Pathway ID |
2-LTR circle formation | REACT:R-HSA-164843 |
2-Oxocarboxylic acid metabolism | KEGG:hsa01210 |
5-Phosphoribose 1-diphosphate biosynthesis | REACT:R-HSA-73843 |
Abacavir metabolism | REACT:R-HSA-2161541 |
Abacavir transmembrane transport | REACT:R-HSA-2161517 |
Abacavir transport and metabolism | REACT:R-HSA-2161522 |
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway | REACT:R-HSA-73930 |
ABC-family proteins mediated transport | REACT:R-HSA-382556 |
ABC transporter disorders | REACT:R-HSA-5619084 |
ABC transporters | KEGG:hsa02010 |