Human Genetic Variants Associated With LongevityMap

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This dataset is a manually curated database of genetic association studies of longevity and reflects current knowledge of the genetics related to human longevity.

Complexity

This dataset comes from The Human Ageing Genomic Resources (HAGR), a repository containing information about the genetics of human aging. Information is obtained from modern approaches such as functional genomics, network analyses, systems biology and evolutionary analyses.

The dataset “Human Genetic Variants Associated With Longevity” is a list of human genetic variants (e.g., SNPs), genes and their chromosomal locations showing the diversity of human genetic association studies of longevity. All entries in this list are manually curated from the literature. Studies were selected following a rigorous literature survey that excluded studies in cohorts of unhealthy individuals at baseline. Both large and small studies are included, including population.

Negative results are also included in the list to provide as much information as possible regarding each gene and variant previously studied in the context of longevity. Each entry refers to a specific observation from a study and is flagged whether results were or not statistically significant. Large-scale studies often have multiple entries in this list. The present list features 551 manually-curated entries, 860 genes and 3025 genetic variants.

Date Created

2013-05-21

Last Modified

2017-06-24

Version

2017-06-24

Update Frequency

Irregular

Temporal Coverage

N/A

Spatial Coverage

N/A

Source

John Snow Labs => Human Ageing Genomic Resources

Source License URL

John Snow Labs Standard License

Source License Requirements

N/A

Source Citation

Budovsky, A., Craig, T., Wang, J., Tacutu, R., Csordas, A., Lourenco, J., Fraifeld, V. E., de Magalhaes, J. P. (2013) "LongevityMap A database of human genetic variants associated with longevity." Trends in Genetics 29559-560.

Keywords

Aging, Longevity, Longevity Map, Human Longevity, Longevity Gene, SNP, Longevity Study, Genetic Association

Other Titles

What are Genetics?, Genomic Testing Associated With Longevity, Genetic Testing Associated With Longevity

Name Description Type Constraints
IdEntry number with individual genes starting with single integer digits. Entries with "G" prefix are entries with multiple genes/variants.stringunique : 1 required : 1
Population_TypeType of human population (depending on the geographical region of the world) under studystringrequired : 1
AssociationEach entry refers to a specific observation from a study and is flagged whether results were or not statistically significant after accessing genetic association with longevity.string-
GenesGene symbol of the gene associated with a longevity or gene studiedstring-
Genetic_VariantsType of genetic variation studied in that particular study. Genetic variants can be single nucleotide polymorphism (SNP) represented by either their "rs" number or position followed by reference/alternate allele, insertion "INS (reference allele) position(alternate allele)" or mitochondrial DNA variations represented by "Mt (reference allele) position (alternate allele)".string-
PubMed_IdPubmed ID numbers from the NCBI website for referring the articlestringrequired : 1
IdPopulation_TypeAssociationGenesGenetic_VariantsPubMed_Id
6FrenchsignificantACEI/D8136829
33ItaliansignificantTHTH9887369
28FrenchsignificantACEI/D9761238
89ItaliansignificantTHTH12297342
91DanishsignificantACEI/D12547486
180DutchsignificantGH1GH115771611
375FinnishsignificantTP5312483296
379ItaliansignificantTP5310463944
8FinnishsignificantAPOBAPOB8155090
280EuropeansignificantTP5323286790