This dataset comes from The Human Ageing Genomic Resources (HAGR), a repository containing information about the genetics of human aging. Information is obtained from modern approaches such as functional genomics, network analyses, systems biology and evolutionary analyses.
The dataset “Human Genetic Variants Associated With Longevity” is a list of human genetic variants (e.g., SNPs), genes and their chromosomal locations showing the diversity of human genetic association studies of longevity. All entries in this list are manually curated from the literature. Studies were selected following a rigorous literature survey that excluded studies in cohorts of unhealthy individuals at baseline. Both large and small studies are included, including population.
Negative results are also included in the list to provide as much information as possible regarding each gene and variant previously studied in the context of longevity. Each entry refers to a specific observation from a study and is flagged whether results were or not statistically significant. Large-scale studies often have multiple entries in this list. The present list features 551 manually-curated entries, 860 genes and 3025 genetic variants.