Human Mitogen Activated Protein MAP Kinase Interactome

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This dataset contains the interaction data published in A Human Map Kinase Interactome by Bandyopadhyay S. et al. – 2010, which reported all interactions for the human protein Mitogen Activated Protein (MAP) kinase as well as associated annotation data obtained from the Biological General Repository for Interaction databases (BIOGRID) for humans including the protein used to find the modification (bait), and annotations on the proteins pulled during the interaction experiment.


This dataset contains interaction data published in a Human MAP kinase interactome by Bandyophayday 2010. MAP kinase is a group of proteins involved in many different biochemical mechanisms in organisms, such as directing cellular responses, via phosphorylation of other proteins to a diverse array of stimuli such as mitogens, osmotic stress, heat shock and proinflammatory cytokines, regulating cell functions including proliferation, gene expression, differentiation, mitosis, cell survival and apoptosis. The dataset annotates the official symbol and aliases for every gene involved as well as the experimental set up used and the score values.

BioGRID interactions are recorded as relationships between two proteins or genes (i.e. they are binary relationships) with an evidence code that supports the interaction and a publication reference. The term “interaction” includes, as well as direct physical binding of two proteins, co-existence in a stable complex and genetic interaction. It should not be assumed that the interaction reported in BioGRID is direct and physical in nature; the experimental system definitions below indicate the nature of the supporting evidence for an interaction between the two biological entities. It should also be noted that some interactions in BioGRID have various levels of evidential support. BioGRID simply curates the result of the experiment from the publication and does not guarantee that any individual interaction is true, well-established or the current consensus view of the community. Curating all available evidence supporting for an interaction enables orthogonal data from various sources to be collated, allowing users of the database to decide confidence in the existence and/or physiological relevance of that interaction.

The Biological General Repository for Interaction Datasets (BioGRID) is a public database that archives and disseminates genetic and protein interaction data from model organisms and humans ( BioGRID currently holds over 980,000 interactions curated from both high-throughput datasets and individual focused studies, as derived from over 55,000 publications in the primary literature. Complete coverage of the entire literature is maintained for budding yeast (S. cerevisiae), fission yeast (S. pombe) and thale cress (A. thaliana), and efforts to expand curation across multiple metazoan species are underway. Current curation drives are focused on particular areas of biology to enable insights into conserved networks and pathways that are relevant to human health. BioGRID provides interaction data from several model organism databases, resources such as Entrez-Gene, SGD, TAIR, FlyBase and other interaction meta-databases.

Description source: Chatr-Aryamontri A, Oughtred R, Boucher L, Rust J, Chang C, Kolas NK, O’Donnell L, Oster S, Theesfeld C, Sellam A, Stark C, Breitkreutz BJ, Dolinski K, Tyers M. The BioGRID interaction database: 2017 update. Nucleic Acids Res. 2016 Dec 14;2017(1) [ Pubmed, NAR ]

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John Snow Labs; Biological General Repository for Interaction Databases;

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Stark C, Breitkreutz BJ, Reguly T, Boucher L, Breitkreutz A, Tyers M. BioGRID a general repository for interaction datasets. Nucleic Acids Res. 2006 Jan 1;34(Database issue)D535-9. PubMed PMID 16381927. Chatr-Aryamontri A, Breitkreutz BJ, Oughtred R, Boucher L, Heinicke S, Chen D, Stark C, Breitkreutz A, Kolas N, O'Donnell L, Reguly T, Nixon J, Ramage L, Winter A, Sellam A, Chang C, Hirschman J, Theesfeld C, Rust J, Livstone MS, Dolinski K, Tyers M. The BioGRID interaction database 2015 update. Nucleic Acids Res. 2015 Jan;43(Database issue)D470-8. PubMed PMID 25428363


Phosphoproteomics, Phosphorylation, Mitogen Activated Protein Kinase, Interactome Database, Mapk Signaling Pathway, Kinome, Body Systems, Human Systems, Organ Systems, Anatomy Organs

Other Titles

MAP Kinase Protein Post Translational Modifications Database, Species Wide Post Translational MAP Kinase Modifications, Annotated Human MAP Kinase Post Translational Modifications, Body Systems Human MAP Kinase Interactome, Human Systems Human MAP Kinase Interactome, Organ Systems Human MAP Kinase Interactome, Anatomy Organs Human MAP Kinase Interactome

Bait_Gene_IDIdentification number of the gene (or translated protein) used as a bait to detect Map kinase phosphorylationintegerrequired : 1 level : Nominal
Bait_Official_SymbolOfficial symbol for the gene (protein) used as a baitstringrequired : 1
Prey_Gene_IDIdentifier for the prey gene, which protein product has been reported to be phosphorylatedintegerrequired : 1 level : Nominal
Prey_Official_SymbolOfficial identifier for the prey gene, which protein product has been reported to be phosphorylatedstringrequired : 1
Experimental_SystemLaboratory method used to find the interaction.stringrequired : 1