Prescription Drugs That Cause Psychiatric Disorders
Keywords
Depression
Psychiatric Disorders
Depression as Side Effect
Depression Causing Drugs
Suicidal Thoughts
Drugs Causing Suicidal Thoughts
Medication Correlated Suicide Risks
This dataset consists of a comprehensive list of prescription drugs which might cause depression or other psychiatric disorders as a side effect. If not treated, these side effects may lead to suicidal ideations and even attempts of failed or successful suicides. The side effects causing psychiatric disorders have further been categorized into very common, common, uncommon, rare and very rare based on their frequency of occurrence.
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Many medications list depression as a side effect—but the evidence linking a particular medication to depression isn’t always conclusive. And because depression is common in people who have certain chronic illnesses, it’s often difficult for doctors to determine whether a particular medication is to blame or if a patient’s depressed state results from the illness itself. Having said that, there are certain medications that do indeed cause depression in some patients. These medications should be used cautiously in people with current or prior depression, or those who are otherwise at high risk for depression, including
– Barbiturates
– Vigabatrin (Sabril)
– Topiramate (Topamax)
– Corticosteroids
– Mefloquine
– Efavirenz (Sustiva)
– Interferon-alpha
Some of these medications may cause depressive symptoms directly by altering levels of neurotransmitters in the central nervous system. Others may do so indirectly by causing fatigue, diminished appetite, sedation or other side effects, which can lead to depression. It’s important for patients to let their doctors know if they experience a depressive episode while taking any of the medications on the list. If the doctor determines that the symptoms are related to a medication or combination of medications that the patient is taking, he or she may alter the dosage or switch to another drug or combination. Any psychiatric side effects reported to the FDA as a result of postmarketing surveillance have also been included in this dataset.
Classes of medications that may contribute to depression or depressive symptoms include:
– Alzheimer’s disease drugs such as donepezil (Aricept) and rivastigmine (Exelon)
– Anti-androgens such as bicalutamide (Casodex) and nilutamide (Nilandron)
– Anti-convulsants such as carbamazepine (Tegretol), lamotrigine (Lamictal) and zonisamide (Zonegran)
– Benzodiazepines such as alprazolam (Xanax), diazepam (Valium), estazolam (ProSom) and lorazepam (Ativan)
– Beta-blockers such as atenolol (Tenormin), propranolol (Inderal) and timolol (Timoptic)
– Calcium channel blockers such as diltiazem (Cardizem, Tiazac and others) and verapamil (Calan)
– Hormone replacement therapies such as estrogen (Premarin) and medroxyprogesterone (Provera)
– Parkinson’s disease medications such as amantadine and levodopa/carbidopa (Duopa, Sinemet)
– Other medications such as clonidine (Catapres, Duraclon), clopidogrel (Plavix) and raloxifene (Evista)
Even when depression is listed as a rare side effect of a medication, be aware that the risk of the medication triggering depression may increase with age because of changing body chemistry. Medication-related depression may lead to suicidal ideations or suicidal attempts in patients with a history of mood disorders and those who are taking multiple medications.
About this Dataset
Data Info
Date Created
2017-08-10
Last Modified
2017-08-10
Version
2017-08-10
Update Frequency
Irregular
Temporal Coverage
N/A
Spatial Coverage
United States
Source
John Snow Labs; Drugs.com, U.S. Food and Drug Administration (FDA);
Source License URL
Source License Requirements
N/A
Source Citation
N/A
Keywords
Depression, Psychiatric Disorders, Depression as Side Effect, Depression Causing Drugs, Suicidal Thoughts, Drugs Causing Suicidal Thoughts
Other Titles
List of Drugs Causing Psychiatric Disorders, List of Drugs Causing Depression as a Side Effect, Prescription Drugs That Cause Depression, Prescription Drugs That Cause Psychiatric Disorders
Data Fields
Name
Description
Type
Constraints
Nonproprietary_Name_of_Drug
Nonproprietary or generic name of the therapeutic drug which causes psychiatric side effects
string
required : 1
Drug_Pharmacological_Class
Pharmacologoical classification of the drug
string
required : 1
Proprietary_Name_of_Drug
Brand name of the drug
string
required : 1
NDC_Product_Code
NDC (National Drug Code) product code of the drug (based on its proprietary name)
string
required : 1
Indication_For_Use
Therapeutic use of the drug
string
required : 1
General_Side_Effects
Most frequently occuring general side effects caused by the drug
string
-
Very_Common_Psychiatric_Side_Effects
Frequently reported psychiatric side effects of the drug (Frequency: 10% or more)
string
-
Common_Psychiatric_Side_Effects
Commonly reported psychiatric side effects of the drug (Frequency: 1% to 10%)
string
-
Uncommon_Psychiatric_Side_Effects
Psychiatric side effects of the drug which are uncommon (Frequency: 0.1% to 1%)
string
-
Rare_Psychiatric_Side_Effects
Rarely reported psychiatric side effects of the drug (Frequency: 0.01% to 0.1%)
string
-
Very_Rare_Psychiatric_Side_Effects
Very rarely reported psychiatric side effects of the drug (Frequency: less than 0.01%)
string
-
Postmarketing_Reports_of_Psychiatric_Side_Effects
Psychiatric side effects of the drug which are reported as a result of postmarketing surveillance
Psychiatric side effects, the frequency of which has not been reported
string
-
Data Preview
Nonproprietary Name of Drug
Drug Pharmacological Class
Proprietary Name of Drug
NDC Product Code
Indication For Use
General Side Effects
Very Common Psychiatric Side Effects
Common Psychiatric Side Effects
Uncommon Psychiatric Side Effects
Rare Psychiatric Side Effects
Very Rare Psychiatric Side Effects
Postmarketing Reports of Psychiatric Side Effects
Frequency Not Reported For Psychiatric Side Effects
Ezetimibe
Cholesterol absorption inhibitors
Zetia
66582-414
Lowers cholesterol in blood
Abdominal fullness, black tarry stools, bleeding gums, bloating
Depression
Interferon alfa-2b
Interferon alpha/ Recombinant Protein
Intron A
0085-0539
Hairy cell leukemia, malignant melanoma, follicular lymphoma, Kaposi's sarcoma caused by AIDS, certain types of genital warts, chronic hepatitis B or C in adults, chronic hepatitis B in children who are at least 1 year old
Acid or sour stomach; bleeding gums; blistering, crusting, irritation, itching, or reddening of the skin; body aches or pain; burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings; change in taste, or bad, unusual, or unpleasant (after) taste; cracked, dry, or scaly skin; hair loss or thinning of the hair; irritation in the mouth; joint pain; lack or loss of strength; loss of memory; muscle or bone pain; pain or tenderness around the eyes and cheekbones; poor concentration; problems with memory; redness and swelling of the gums; stuffy or runny nose; swollen joints
Depression (up to 40%), confusion (up to 12%), insomnia (up to 12%), anxiety, emotional lability, nervousness, agitation Common (1% to 10%): Decreased libido, sleep disorder Uncommon (0.1% to 1%): Suicidal ideation, suicide attempt, suicide Rare (0.01% to 0.1%): Aggressive behavior (sometimes directed against others), psychosis (including hallucinations) Very rare (less than 0.01%): Abnormal thinking, apathy, depression aggravated, feeling of ebriety, neurosis, paroniria, personality disorder Frequency not reported: Abnormal dreaming, delirium, manic depression, mania, psychosis, mental status change, bipolar disorders Postmarketing reports: Homicidal ideation
Prednisone
Corticosteroids
Perrigo Prednisone
10768-7085
Various allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders.
Aggression; agitation; blurred vision; decrease in the amount of urine; dizziness; fast, slow, pounding, or irregular heartbeat or pulse; headache; irritability; mood changes; noisy, rattling breathing; numbness or tingling in the arms or legs; pounding in the ears; shortness of breath; swelling of the fingers, hands, feet, or lower legs; trouble thinking, speaking, or walking; troubled breathing at rest; weight gain
Amnesia, anxiety, delirium, depression, emotional instability and irritability, euphoria, hallucinations, severe psychiatric symptoms, insomnia, long-term memory loss, mania, mood swings, neuritis, neuropathy, paresthesia, personality changes, psychiatric disorders including steroid psychoses or aggravation of preexisting psychiatric conditions, restlessness, schizophrenia, verbal memory loss, withdrawn behavior
Triamcinolone
Corticosteroids
Triamcinolone Acetonide
53217-014
Various allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders.
Aggression; agitation; blurred vision; decrease in the amount of urine; dizziness; fast, slow, pounding, or irregular heartbeat or pulse; headache; irritability; mood changes; noisy, rattling breathing; numbness or tingling in the arms or legs; pounding in the ears; shortness of breath; swelling of the fingers, hands, feet, or lower legs; trouble thinking, speaking, or walking; troubled breathing at rest; weight gain
Amnesia, anxiety, delirium, depression, emotional instability and irritability, euphoria, hallucinations, severe psychiatric symptoms, insomnia, long-term memory loss, mania, mood swings, neuritis, neuropathy, paresthesia, personality changes, psychiatric disorders including steroid psychoses or aggravation of preexisting psychiatric conditions, restlessness, schizophrenia, verbal memory loss, withdrawn behavior
Lorazepam
Benzodiazepine
Ativan
65084-463
Anxiety disorders
Agitation, sedation, and tremor, dizziness, drowsiness, and hypersomnia
Insomnia, sedative prior to anesthesia for surgery
Allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Drowsiness, feeling tired, "hangover" effect (drowsiness the day after a dose) headache, dizziness memory problems dry mouth upset stomach feeling restless or excited (especially in children)
Venlafaxine
SSNRI (Selective Serotonin and Norepinephrine Reuptake Inhibitor)
Effexor
61919-938
Major depressive disorder, anxiety, and panic disorder
Demos
