Others titles

  • List of Drugs Causing Psychiatric Disorders
  • List of Drugs Causing Depression as a Side Effect
  • Prescription Drugs That Cause Depression
  • Prescription Drugs That Cause Psychiatric Disorders

Keywords

  • Depression
  • Psychiatric Disorders
  • Depression as Side Effect
  • Depression Causing Drugs
  • Suicidal Thoughts
  • Drugs Causing Suicidal Thoughts

Medication Correlated Suicide Risks

This dataset consists of a comprehensive list of prescription drugs which might cause depression or other psychiatric disorders as a side effect. If not treated, these side effects may lead to suicidal ideations and even attempts of failed or successful suicides. The side effects causing psychiatric disorders have further been categorized into very common, common, uncommon, rare and very rare based on their frequency of occurrence.

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Description

Many medications list depression as a side effect—but the evidence linking a particular medication to depression isn’t always conclusive. And because depression is common in people who have certain chronic illnesses, it’s often difficult for doctors to determine whether a particular medication is to blame or if a patient’s depressed state results from the illness itself. Having said that, there are certain medications that do indeed cause depression in some patients. These medications should be used cautiously in people with current or prior depression, or those who are otherwise at high risk for depression, including
– Barbiturates
– Vigabatrin (Sabril)
– Topiramate (Topamax)
– Corticosteroids
– Mefloquine
– Efavirenz (Sustiva)
– Interferon-alpha

Some of these medications may cause depressive symptoms directly by altering levels of neurotransmitters in the central nervous system. Others may do so indirectly by causing fatigue, diminished appetite, sedation or other side effects, which can lead to depression. It’s important for patients to let their doctors know if they experience a depressive episode while taking any of the medications on the list. If the doctor determines that the symptoms are related to a medication or combination of medications that the patient is taking, he or she may alter the dosage or switch to another drug or combination. Any psychiatric side effects reported to the FDA as a result of postmarketing surveillance have also been included in this dataset.

Classes of medications that may contribute to depression or depressive symptoms include:

– Alzheimer’s disease drugs such as donepezil (Aricept) and rivastigmine (Exelon)
– Anti-androgens such as bicalutamide (Casodex) and nilutamide (Nilandron)
– Anti-convulsants such as carbamazepine (Tegretol), lamotrigine (Lamictal) and zonisamide (Zonegran)
– Benzodiazepines such as alprazolam (Xanax), diazepam (Valium), estazolam (ProSom) and lorazepam (Ativan)
– Beta-blockers such as atenolol (Tenormin), propranolol (Inderal) and timolol (Timoptic)
– Calcium channel blockers such as diltiazem (Cardizem, Tiazac and others) and verapamil (Calan)
– Hormone replacement therapies such as estrogen (Premarin) and medroxyprogesterone (Provera)
– Parkinson’s disease medications such as amantadine and levodopa/carbidopa (Duopa, Sinemet)
– Other medications such as clonidine (Catapres, Duraclon), clopidogrel (Plavix) and raloxifene (Evista)

Even when depression is listed as a rare side effect of a medication, be aware that the risk of the medication triggering depression may increase with age because of changing body chemistry. Medication-related depression may lead to suicidal ideations or suicidal attempts in patients with a history of mood disorders and those who are taking multiple medications.

About this Dataset

Data Info

Date Created

2017-08-10

Last Modified

2017-08-10

Version

2017-08-10

Update Frequency

Irregular

Temporal Coverage

N/A

Spatial Coverage

United States

Source

John Snow Labs; Drugs.com, U.S. Food and Drug Administration (FDA);

Source License URL

Source License Requirements

N/A

Source Citation

N/A

Keywords

Depression, Psychiatric Disorders, Depression as Side Effect, Depression Causing Drugs, Suicidal Thoughts, Drugs Causing Suicidal Thoughts

Other Titles

List of Drugs Causing Psychiatric Disorders, List of Drugs Causing Depression as a Side Effect, Prescription Drugs That Cause Depression, Prescription Drugs That Cause Psychiatric Disorders

Data Fields

Name Description Type Constraints
Nonproprietary_Name_of_DrugNonproprietary or generic name of the therapeutic drug which causes psychiatric side effectsstringrequired : 1
Drug_Pharmacological_ClassPharmacologoical classification of the drugstringrequired : 1
Proprietary_Name_of_DrugBrand name of the drugstringrequired : 1
NDC_Product_CodeNDC (National Drug Code) product code of the drug (based on its proprietary name)stringrequired : 1
Indication_For_UseTherapeutic use of the drugstringrequired : 1
General_Side_EffectsMost frequently occuring general side effects caused by the drugstring-
Very_Common_Psychiatric_Side_EffectsFrequently reported psychiatric side effects of the drug (Frequency: 10% or more)string-
Common_Psychiatric_Side_EffectsCommonly reported psychiatric side effects of the drug (Frequency: 1% to 10%)string-
Uncommon_Psychiatric_Side_EffectsPsychiatric side effects of the drug which are uncommon (Frequency: 0.1% to 1%)string-
Rare_Psychiatric_Side_EffectsRarely reported psychiatric side effects of the drug (Frequency: 0.01% to 0.1%)string-
Very_Rare_Psychiatric_Side_EffectsVery rarely reported psychiatric side effects of the drug (Frequency: less than 0.01%)string-
Postmarketing_Reports_of_Psychiatric_Side_EffectsPsychiatric side effects of the drug which are reported as a result of postmarketing surveillancestring-
Frequency_Not_Reported_For_Psychiatric_Side_EffectsPsychiatric side effects, the frequency of which has not been reportedstring-

Data Preview

Nonproprietary Name of DrugDrug Pharmacological ClassProprietary Name of DrugNDC Product CodeIndication For UseGeneral Side EffectsVery Common Psychiatric Side EffectsCommon Psychiatric Side EffectsUncommon Psychiatric Side EffectsRare Psychiatric Side EffectsVery Rare Psychiatric Side EffectsPostmarketing Reports of Psychiatric Side EffectsFrequency Not Reported For Psychiatric Side Effects
EzetimibeCholesterol absorption inhibitorsZetia66582-414Lowers cholesterol in bloodAbdominal fullness, black tarry stools, bleeding gums, bloatingDepression
Interferon alfa-2bInterferon alpha/ Recombinant ProteinIntron A0085-0539Hairy cell leukemia, malignant melanoma, follicular lymphoma, Kaposi's sarcoma caused by AIDS, certain types of genital warts, chronic hepatitis B or C in adults, chronic hepatitis B in children who are at least 1 year oldAcid or sour stomach; bleeding gums; blistering, crusting, irritation, itching, or reddening of the skin; body aches or pain; burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings; change in taste, or bad, unusual, or unpleasant (after) taste; cracked, dry, or scaly skin; hair loss or thinning of the hair; irritation in the mouth; joint pain; lack or loss of strength; loss of memory; muscle or bone pain; pain or tenderness around the eyes and cheekbones; poor concentration; problems with memory; redness and swelling of the gums; stuffy or runny nose; swollen jointsDepression (up to 40%), confusion (up to 12%), insomnia (up to 12%), anxiety, emotional lability, nervousness, agitation Common (1% to 10%): Decreased libido, sleep disorder Uncommon (0.1% to 1%): Suicidal ideation, suicide attempt, suicide Rare (0.01% to 0.1%): Aggressive behavior (sometimes directed against others), psychosis (including hallucinations) Very rare (less than 0.01%): Abnormal thinking, apathy, depression aggravated, feeling of ebriety, neurosis, paroniria, personality disorder Frequency not reported: Abnormal dreaming, delirium, manic depression, mania, psychosis, mental status change, bipolar disorders Postmarketing reports: Homicidal ideation
PrednisoneCorticosteroidsPerrigo Prednisone10768-7085Various allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders.Aggression; agitation; blurred vision; decrease in the amount of urine; dizziness; fast, slow, pounding, or irregular heartbeat or pulse; headache; irritability; mood changes; noisy, rattling breathing; numbness or tingling in the arms or legs; pounding in the ears; shortness of breath; swelling of the fingers, hands, feet, or lower legs; trouble thinking, speaking, or walking; troubled breathing at rest; weight gainAmnesia, anxiety, delirium, depression, emotional instability and irritability, euphoria, hallucinations, severe psychiatric symptoms, insomnia, long-term memory loss, mania, mood swings, neuritis, neuropathy, paresthesia, personality changes, psychiatric disorders including steroid psychoses or aggravation of preexisting psychiatric conditions, restlessness, schizophrenia, verbal memory loss, withdrawn behavior
TriamcinoloneCorticosteroidsTriamcinolone Acetonide53217-014Various allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders.Aggression; agitation; blurred vision; decrease in the amount of urine; dizziness; fast, slow, pounding, or irregular heartbeat or pulse; headache; irritability; mood changes; noisy, rattling breathing; numbness or tingling in the arms or legs; pounding in the ears; shortness of breath; swelling of the fingers, hands, feet, or lower legs; trouble thinking, speaking, or walking; troubled breathing at rest; weight gainAmnesia, anxiety, delirium, depression, emotional instability and irritability, euphoria, hallucinations, severe psychiatric symptoms, insomnia, long-term memory loss, mania, mood swings, neuritis, neuropathy, paresthesia, personality changes, psychiatric disorders including steroid psychoses or aggravation of preexisting psychiatric conditions, restlessness, schizophrenia, verbal memory loss, withdrawn behavior
LorazepamBenzodiazepineAtivan65084-463Anxiety disordersAgitation, sedation, and tremor, dizziness, drowsiness, and hypersomniaDepression, emotional lability, confusion Hallucinations, insomnia, psychosis, excitability, irritability, aggressive behavior, agitation, hostility, anxiety, vivid dreams, hyperactivity, organic disinhibition, depersonalization, apathy, excitement, feeling mad, illusion, nightmares, sleep disorders, suicide ideation, rage
SecobarbitalCNS depressant/ barbituratesSeconal Sodium0187-4220Insomnia, sedative prior to anesthesia for surgeryAllergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Drowsiness, feeling tired, "hangover" effect (drowsiness the day after a dose) headache, dizziness memory problems dry mouth upset stomach feeling restless or excited (especially in children)
VenlafaxineSSNRI (Selective Serotonin and Norepinephrine Reuptake Inhibitor)Effexor61919-938Major depressive disorder, anxiety, and panic disorderAnorgasmia, asthenia, constipation, dizziness, drowsiness, insomnia, nausea, nervousness, headache, anorexia, decreased appetite, delayed ejaculation, diaphoresis, and xerostomia, abdominal pain, anxiety, blurred vision, hypertension, impotence, tremor, visual disturbance, vomiting, diarrhea, dyspepsia, increased serum cholesterol, pharyngitis, vasodilatation, weight loss, decreased libido, increased dream activity, yawning, abnormal dreams, and flatulenceInsomnia (up to 25%)Abnormal dreams, depression, agitation, anxietyHallucination, derealization, apathy, hypomaniaMania Suicidal ideation, suicidal behaviors, delirium, aggression
TopiramateAnticonvulsantTopamax61919-189SeizuresAnxiety, ataxia, confusion, diarrhea, diplopia, dizziness, drowsiness, dysphasia, fatigue, lack of concentration, memory impairment, nausea, nervousness, paresthesia, psychomotor disturbance, speech disturbance, depression, visual disturbance, weight loss, dysgeusia, mood changes, anorexiaSomnolence (15%), memory loss (10%), depressionDepression, difficulty with concentration/attention, anxiety psychomotor slowing, altered mood, confusion, cognitive difficulty, bradyphrenia, decreased libido, expressive language disorder, disorientation, aggression, aggression, anger, abnormal behaviorSuicidal ideation, suicide attempt, hallucination, psychotic disorder, hallucination auditory, hallucination visual, apathy, lack of spontaneous speech, sleep disorder, affect lability, restlessness, crying, dysphemia, euphoria, paranoia, perseveration, panic attack, tearfulness, reading disorder, flat affect, thinking abnormal, listlessness, middle insomnia, distractibility, early morning awakening, panic reaction, elevated moodMania, panic disorder, feelings of despair, hypomania
ParoxetineSSRIs (selective serotonin reuptake inhibitor)Paxil60505-0402Depression, obsessive-compulsive disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD)Asthenia, constipation, diarrhea, dizziness, drowsiness, ejaculatory disorder, erectile dysfunction, insomnia, male genital disease, nausea, headache, decreased libido, delayed ejaculation, diaphoresis, and xerostomiaInsomniaAbnormal dreams, agitation, anxiety, depersonalization, depression, drugged feeling, emotional lability, lack of emotion, nervousnessAbnormal thinking, alcohol abuse, bruxism, euphoria, hallucinations, hostility, lack of emotion, manic reaction, neurosis, paranoid reactionAbnormal electroencephalogram, antisocial reaction, bulimia, delirium, delusions, drug dependence, hysteria, irritability, manic-depressive reaction, panic attacks, psychosis, psychotic depression, stupor, withdrawal syndrome Suicidal ideation and behavior
ParoxetineSSRIs (selective serotonin reuptake inhibitor)Pexeva61786-603Depression, obsessive-compulsive disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD)Asthenia, constipation, diarrhea, dizziness, drowsiness, ejaculatory disorder, erectile dysfunction, insomnia, male genital disease, nausea, headache, decreased libido, delayed ejaculation, diaphoresis, and xerostomiaInsomniaAbnormal dreams, agitation, anxiety, depersonalization, depression, drugged feeling, emotional lability, lack of emotion, nervousnessAbnormal thinking, alcohol abuse, bruxism, euphoria, hallucinations, hostility, lack of emotion, manic reaction, neurosis, paranoid reactionAbnormal electroencephalogram, antisocial reaction, bulimia, delirium, delusions, drug dependence, hysteria, irritability, manic-depressive reaction, panic attacks, psychosis, psychotic depression, stupor, withdrawal syndrome Suicidal ideation and behavior