Others titles
- List of Drugs Causing Psychiatric Disorders
- List of Drugs Causing Depression as a Side Effect
- Prescription Drugs That Cause Depression
- Prescription Drugs That Cause Psychiatric Disorders
Keywords
- Depression
- Psychiatric Disorders
- Depression as Side Effect
- Depression Causing Drugs
- Suicidal Thoughts
- Drugs Causing Suicidal Thoughts
Medication Correlated Suicide Risks

This dataset consists of a comprehensive list of prescription drugs which might cause depression or other psychiatric disorders as a side effect. If not treated, these side effects may lead to suicidal ideations and even attempts of failed or successful suicides. The side effects causing psychiatric disorders have further been categorized into very common, common, uncommon, rare and very rare based on their frequency of occurrence.
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Description
Many medications list depression as a side effect—but the evidence linking a particular medication to depression isn’t always conclusive. And because depression is common in people who have certain chronic illnesses, it’s often difficult for doctors to determine whether a particular medication is to blame or if a patient’s depressed state results from the illness itself. Having said that, there are certain medications that do indeed cause depression in some patients. These medications should be used cautiously in people with current or prior depression, or those who are otherwise at high risk for depression, including
– Barbiturates
– Vigabatrin (Sabril)
– Topiramate (Topamax)
– Corticosteroids
– Mefloquine
– Efavirenz (Sustiva)
– Interferon-alpha
Some of these medications may cause depressive symptoms directly by altering levels of neurotransmitters in the central nervous system. Others may do so indirectly by causing fatigue, diminished appetite, sedation or other side effects, which can lead to depression. It’s important for patients to let their doctors know if they experience a depressive episode while taking any of the medications on the list. If the doctor determines that the symptoms are related to a medication or combination of medications that the patient is taking, he or she may alter the dosage or switch to another drug or combination. Any psychiatric side effects reported to the FDA as a result of postmarketing surveillance have also been included in this dataset.
Classes of medications that may contribute to depression or depressive symptoms include:
– Alzheimer’s disease drugs such as donepezil (Aricept) and rivastigmine (Exelon)
– Anti-androgens such as bicalutamide (Casodex) and nilutamide (Nilandron)
– Anti-convulsants such as carbamazepine (Tegretol), lamotrigine (Lamictal) and zonisamide (Zonegran)
– Benzodiazepines such as alprazolam (Xanax), diazepam (Valium), estazolam (ProSom) and lorazepam (Ativan)
– Beta-blockers such as atenolol (Tenormin), propranolol (Inderal) and timolol (Timoptic)
– Calcium channel blockers such as diltiazem (Cardizem, Tiazac and others) and verapamil (Calan)
– Hormone replacement therapies such as estrogen (Premarin) and medroxyprogesterone (Provera)
– Parkinson’s disease medications such as amantadine and levodopa/carbidopa (Duopa, Sinemet)
– Other medications such as clonidine (Catapres, Duraclon), clopidogrel (Plavix) and raloxifene (Evista)
Even when depression is listed as a rare side effect of a medication, be aware that the risk of the medication triggering depression may increase with age because of changing body chemistry. Medication-related depression may lead to suicidal ideations or suicidal attempts in patients with a history of mood disorders and those who are taking multiple medications.
About this Dataset
Data Info
Date Created | 2017-08-10 |
---|---|
Last Modified | 2017-08-10 |
Version | 2017-08-10 |
Update Frequency | Irregular |
Temporal Coverage | N/A |
Spatial Coverage | United States |
Source | John Snow Labs; Drugs.com, U.S. Food and Drug Administration (FDA); |
Source License URL | |
Source License Requirements | N/A |
Source Citation | N/A |
Keywords | Depression, Psychiatric Disorders, Depression as Side Effect, Depression Causing Drugs, Suicidal Thoughts, Drugs Causing Suicidal Thoughts |
Other Titles | List of Drugs Causing Psychiatric Disorders, List of Drugs Causing Depression as a Side Effect, Prescription Drugs That Cause Depression, Prescription Drugs That Cause Psychiatric Disorders |
Data Fields
Name | Description | Type | Constraints |
---|---|---|---|
Nonproprietary_Name_of_Drug | Nonproprietary or generic name of the therapeutic drug which causes psychiatric side effects | string | required : 1 |
Drug_Pharmacological_Class | Pharmacologoical classification of the drug | string | required : 1 |
Proprietary_Name_of_Drug | Brand name of the drug | string | required : 1 |
NDC_Product_Code | NDC (National Drug Code) product code of the drug (based on its proprietary name) | string | required : 1 |
Indication_For_Use | Therapeutic use of the drug | string | required : 1 |
General_Side_Effects | Most frequently occuring general side effects caused by the drug | string | - |
Very_Common_Psychiatric_Side_Effects | Frequently reported psychiatric side effects of the drug (Frequency: 10% or more) | string | - |
Common_Psychiatric_Side_Effects | Commonly reported psychiatric side effects of the drug (Frequency: 1% to 10%) | string | - |
Uncommon_Psychiatric_Side_Effects | Psychiatric side effects of the drug which are uncommon (Frequency: 0.1% to 1%) | string | - |
Rare_Psychiatric_Side_Effects | Rarely reported psychiatric side effects of the drug (Frequency: 0.01% to 0.1%) | string | - |
Very_Rare_Psychiatric_Side_Effects | Very rarely reported psychiatric side effects of the drug (Frequency: less than 0.01%) | string | - |
Postmarketing_Reports_of_Psychiatric_Side_Effects | Psychiatric side effects of the drug which are reported as a result of postmarketing surveillance | string | - |
Frequency_Not_Reported_For_Psychiatric_Side_Effects | Psychiatric side effects, the frequency of which has not been reported | string | - |
Data Preview
Nonproprietary_Name_of_Drug | Drug_Pharmacological_Class | Proprietary_Name_of_Drug | NDC_Product_Code | Indication_For_Use | General_Side_Effects | Very_Common_Psychiatric_Side_Effects | Common_Psychiatric_Side_Effects | Uncommon_Psychiatric_Side_Effects | Rare_Psychiatric_Side_Effects | Very_Rare_Psychiatric_Side_Effects | Postmarketing_Reports_of_Psychiatric_Side_Effects | Frequency_Not_Reported_For_Psychiatric_Side_Effects |
Ezetimibe | Cholesterol absorption inhibitors | Zetia | 66582-414 | Lowers cholesterol in blood | Abdominal fullness, black tarry stools, bleeding gums, bloating | Depression | ||||||
Bicalutamide | Antiandrogens | Casodex | 0310-0705 | Prostate cancer | Abdominal pain, nausea, mastalgia, flu-like symptoms, gynecomastia, vomiting, and anorexia | Insomnia | Depression | |||||
Nilutamide | Antiandrogens | Nilandron | 0088-1111 | Prostate cancer | Nausea, nocturnal amblyopia, decreased libido, hemeralopia, visual disturbance, chromatopsia, and loss of body hair | Insomnia | Depression | |||||
Gentamicin | Aminoglycoside Antibacterial | Gentak | 70518-0633 | severe or serious bacterial infections | Nausea, vomiting, stomach upset, loss of appetite, pain/irritation/redness at the injection site | Depression | ||||||
Raloxifene | Hormone /antineoplastic | Evista | 55289-266 | Osteoporosis, invasive breast cancer in women who are past menopause | Infection, flu-like symptoms, hot flash, sinusitis, leg cramps | Depression, insomnia | ||||||
Gentamicin | Aminoglycoside Antibacterial | Gentamicin | 63323-173 | severe or serious bacterial infections | Nausea, vomiting, stomach upset, loss of appetite, pain/irritation/redness at the injection site | Depression | ||||||
Oxycodone | Opioid Agonist | Oxycontin | 60760-049 | Moderate to severe pain | Constipation, drowsiness, nausea, pruritus, and vomiting, asthenia, diaphoresis, and xerostomia | Paranoia, psychosis, hallucinations, agitation, anxiety | ||||||
Clopidogrel | Platelet aggregation inhibitor | Plavix | 21695-665 | Prevents blood clots after a recent heart attack or stroke | Easy bleeding/bruising, stomach upset/pain, diarrhea, and constipation | Depression | Hallucinations, confusion | |||||
Aspirin/Oxycodone | Opioid Agonist | Endodan | 16590-947 | Moderate to moderately severe pain | Nausea, vomiting, upset stomach, constipation, dizziness, drowsiness, headache, increased sweating, dry mouth, lightheadedness, or weakness | Paranoia, psychosis, and hallucinations | ||||||
Simvastatin | HMG CoA reductase inhibitor (Statins) | Zocor | 0006-0543 | lowers cholesterol and triglycerides in blood | Eczema and increased creatine phosphokinase | Depression, suicidal thoughts, delusions, paranoia, agitation, decreased libido, anxiety, insomnia, nightmares |