Medication Correlated Suicide Risks

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This dataset consists of a comprehensive list of prescription drugs which might cause depression or other psychiatric disorders as a side effect. If not treated, these side effects may lead to suicidal ideations and even attempts of failed or successful suicides. The side effects causing psychiatric disorders have further been categorized into very common, common, uncommon, rare and very rare based on their frequency of occurrence. Any psychiatric side effects reported to the FDA as a result of postmarketing surveillance have also been included in this dataset.

Complexity

Many medications list depression as a side effect—but the evidence linking a particular medication to depression isn’t always conclusive. And because depression is common in people who have certain chronic illnesses, it’s often difficult for doctors to determine whether a particular medication is to blame or if a patient’s depressed state results from the illness itself. Having said that, there are certain medications that do indeed cause depression in some patients. These medications should be used cautiously in people with current or prior depression, or those who are otherwise at high risk for depression, including
– Barbiturates
– Vigabatrin (Sabril)
– Topiramate (Topamax)
– Corticosteroids
– Mefloquine
– Efavirenz (Sustiva)
– Interferon-alpha

Some of these medications may cause depressive symptoms directly by altering levels of neurotransmitters in the central nervous system. Others may do so indirectly by causing fatigue, diminished appetite, sedation or other side effects, which can lead to depression. It’s important for patients to let their doctors know if they experience a depressive episode while taking any of the medications on the list. If the doctor determines that the symptoms are related to a medication or combination of medications that the patient is taking, he or she may alter the dosage or switch to another drug or combination.

Classes of medications that may contribute to depression or depressive symptoms include:

– Alzheimer’s disease drugs such as donepezil (Aricept) and rivastigmine (Exelon)
– Anti-androgens such as bicalutamide (Casodex) and nilutamide (Nilandron)
– Anti-convulsants such as carbamazepine (Tegretol), lamotrigine (Lamictal) and zonisamide (Zonegran)
– Benzodiazepines such as alprazolam (Xanax), diazepam (Valium), estazolam (ProSom) and lorazepam (Ativan)
– Beta-blockers such as atenolol (Tenormin), propranolol (Inderal) and timolol (Timoptic)
– Calcium channel blockers such as diltiazem (Cardizem, Tiazac and others) and verapamil (Calan)
– Hormone replacement therapies such as estrogen (Premarin) and medroxyprogesterone (Provera)
– Parkinson’s disease medications such as amantadine and levodopa/carbidopa (Duopa, Sinemet)
– Other medications such as clonidine (Catapres, Duraclon), clopidogrel (Plavix) and raloxifene (Evista)

Even when depression is listed as a rare side effect of a medication, be aware that the risk of the medication triggering depression may increase with age because of changing body chemistry. Medication-related depression may lead to suicidal ideations or suicidal attempts in patients with a history of mood disorders and those who are taking multiple medications.

Date Created

2017-08-10

Last Modified

2017-08-10

Version

2017-08-10

Update Frequency

Irregular

Temporal Coverage

N/A

Spatial Coverage

United States

Source

John Snow Labs => Drugs.com, U.S. Food and Drug Administration (FDA)

Source License URL

John Snow Labs Standard License

Source License Requirements

N/A

Source Citation

N/A

Keywords

Depression, Psychiatric Disorders, Depression as Side Effect, Depression Causing Drugs, Suicidal Thoughts, Drugs Causing Suicidal Thoughts

Other Titles

List of Drugs Causing Psychiatric Disorders, List of Drugs Causing Depression as a Side Effect, Prescription Drugs That Cause Depression, Prescription Drugs That Cause Psychiatric Disorders

NameDescriptionTypeConstraints
Nonproprietary_Name_of_DrugNonproprietary or generic name of the therapeutic drug which causes psychiatric side effectsstringrequired : 1
Drug_Pharmacological_ClassPharmacologoical classification of the drugstringrequired : 1
Proprietary_Name_of_DrugBrand name of the drugstringrequired : 1
NDC_Product_CodeNDC (National Drug Code) product code of the drug (based on its proprietary name)stringrequired : 1
Indication_For_UseTherapeutic use of the drugstringrequired : 1
General_Side_EffectsMost frequently occuring general side effects caused by the drugstring-
Very_Common_Psychiatric_Side_EffectsFrequently reported psychiatric side effects of the drug (Frequency: 10% or more)string-
Common_Psychiatric_Side_EffectsCommonly reported psychiatric side effects of the drug (Frequency: 1% to 10%)string-
Uncommon_Psychiatric_Side_EffectsPsychiatric side effects of the drug which are uncommon (Frequency: 0.1% to 1%)string-
Rare_Psychiatric_Side_EffectsRarely reported psychiatric side effects of the drug (Frequency: 0.01% to 0.1%)string-
Very_Rare_Psychiatric_Side_EffectsVery rarely reported psychiatric side effects of the drug (Frequency: less than 0.01%)string-
Postmarketing_Reports_of_Psychiatric_Side_EffectsPsychiatric side effects of the drug which are reported as a result of postmarketing surveillancestring-
Frequency_Not_Reported_For_Psychiatric_Side_EffectsPsychiatric side effects, the frequency of which has not been reportedstring-
Nonproprietary_Name_of_DrugDrug_Pharmacological_ClassProprietary_Name_of_DrugNDC_Product_CodeIndication_For_UseGeneral_Side_EffectsVery_Common_Psychiatric_Side_EffectsCommon_Psychiatric_Side_EffectsUncommon_Psychiatric_Side_EffectsRare_Psychiatric_Side_EffectsVery_Rare_Psychiatric_Side_EffectsPostmarketing_Reports_of_Psychiatric_Side_EffectsFrequency_Not_Reported_For_Psychiatric_Side_Effects
EzetimibeCholesterol absorption inhibitorsZetia66582-414Lowers cholesterol in bloodAbdominal fullness, black tarry stools, bleeding gums, bloatingDepression
BicalutamideAntiandrogensCasodex0310-0705Prostate cancerAbdominal pain, nausea, mastalgia, flu-like symptoms, gynecomastia, vomiting, and anorexiaInsomniaDepression
NilutamideAntiandrogensNilandron0088-1111Prostate cancerNausea, nocturnal amblyopia, decreased libido, hemeralopia, visual disturbance, chromatopsia, and loss of body hairInsomniaDepression
GentamicinAminoglycoside AntibacterialGentak70518-0633severe or serious bacterial infectionsNausea, vomiting, stomach upset, loss of appetite, pain/irritation/redness at the injection siteDepression
RaloxifeneHormone /antineoplasticEvista55289-266Osteoporosis, invasive breast cancer in women who are past menopauseInfection, flu-like symptoms, hot flash, sinusitis, leg crampsDepression, insomnia
GentamicinAminoglycoside AntibacterialGentamicin63323-173severe or serious bacterial infectionsNausea, vomiting, stomach upset, loss of appetite, pain/irritation/redness at the injection siteDepression
OxycodoneOpioid AgonistOxycontin60760-049Moderate to severe painConstipation, drowsiness, nausea, pruritus, and vomiting, asthenia, diaphoresis, and xerostomiaParanoia, psychosis, hallucinations, agitation, anxiety
ClopidogrelPlatelet aggregation inhibitorPlavix21695-665Prevents blood clots after a recent heart attack or strokeEasy bleeding/bruising, stomach upset/pain, diarrhea, and constipationDepressionHallucinations, confusion
Aspirin/OxycodoneOpioid AgonistEndodan16590-947Moderate to moderately severe painNausea, vomiting, upset stomach, constipation, dizziness, drowsiness, headache, increased sweating, dry mouth, lightheadedness, or weaknessParanoia, psychosis, and hallucinations
SimvastatinHMG CoA reductase inhibitor (Statins)Zocor0006-0543lowers cholesterol and triglycerides in bloodEczema and increased creatine phosphokinaseDepression, suicidal thoughts, delusions, paranoia, agitation, decreased libido, anxiety, insomnia, nightmares