Pharmacology Complete List of Endogenous Ligands and Other Peptides

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This dataset shows the complete list of Endogenous Ligands and Other Peptides from the Guide to PHARMACOLOGY; an online, open-access portal to pharmacological information on all the human targets of prescription drugs, which is the product from the collaboration of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS).

Complexity

The data types captured in this dataset include target nomenclature, pharmacological data, and ligand structures. Organisms isolated in this data are from human, mouse, and rat.

In future versions, the plan is to add resources for education and training in pharmacological principles and techniques along with research guidelines and overviews of key topics. It is the hope of IUPHAR/BPS Guide to PHARMACOLOGY to be useful for researchers and students in pharmacology and drug discovery and provide the general public with accurate information on the basic science underlying drug action.

The information provided in this dataset shows the initial view or landing pages for each target family that provides expert-curated overviews of the key properties and selective ligands and tool compounds available. Additional information can be found also in other databases including Ensembl, UniProt, PubChem, ChEMBL, and DrugBank, as well as curated chemical information and literature citations in PubMed.

Endogenous ligands include metabolites, hormones, neurotransmitters, and cytokines.

Date Created

2011

Last Modified

2017-04-24

Version

2017.3

Update Frequency

Quarterly

Temporal Coverage

N/A

Spatial Coverage

N/A

Source

John Snow Labs => International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS) Guide to PHARMACOLOGY

Source License URL

John Snow Labs Standard License

Source License Requirements

N/A

Source Citation

Southan C, Sharman JL, Benson HE, Faccenda E, Pawson AJ, Alexander SPH, Buneman OP, Davenport AP, McGrath JC, Peters JA, Spedding M, Catterall WA, Fabbro D, Davies JA; NC-IUPHAR. (2016) The IUPHAR/BPS Guide to PHARMACOLOGY in 2016 towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucl. Acids Res. 44 (Database Issue) D1054-68

Keywords

Peptide, Antigen Presenting Cells, Endogenous Opioid Peptides, Antimicrobial Peptides, Endogenous Opioids, Antimicrobial, Peptide, Peptides for Skin

Other Titles

Pharmacology Complete List of Peptides, Pharmacology Complete List of Endogenous Opioid Peptides, Pharmacology Complete List of Antimicrobial Peptides, Pharmacology Complete List of Endogenous Opioids

NameDescriptionTypeConstraints
Ligand_IdThe Guide to Pharmacology (GtP) ligand identifierintegerunique : 1 required : 1 level : Nominal
Ligand_NameThe name of the ligand wherein the Guide to Pharmacology (GtoPdb) context, the term ‘ligand’ is used mostly for small molecule-to-large molecule interactions but it does extend to selected protein-protein interactions (e.g. cytokines-to-receptors or antibodies-to-cytokines).stringrequired : 1
SpeciesThe species which endogenously express a particular peptide ligand sequencestring-
Endogenous_or_Peptide_TypeEither endogenous (in human, mouse or rat) or other (in other species or synthetic) peptide.stringrequired : 1
Subunit_IdsThe Guide to Pharmacology (GtP) ligand identifiers of any subunit polypeptidesstring-
Subunit_NamesThe names of any subunits that make up a multimeric proteinstring-
Is_ApprovedA version of this peptide (possibly produced synthetically) is or has in the past been approved for human clinical use by a regulatory agencyboolean-
Is_WithdrawnThe drug is no longer approved for its original clinical use in one or more countriesboolean-
Is_LabelledThe peptide has been labeled with a chemical group such as a fluorescent tag or unstable isotopeboolean-
Is_RadioactiveHas been labeled with a radioactive isotopeboolean-
PubChem_Substance_IdentifierThe PubChem Substance identifier assigned when we deposited the ligand in PubChemstring-
PubChem_Compound_DatabaseCurated PubChem Compound database linkintegerlevel : Ordinal
UniProt_IdThe UniProtKB/SwissProt Accession for the (parent) peptide sequencestring-
International_Non_Proprietary_NameThe International Non-proprietary Name (INN)assigned by the WHOstring-
Single_Letter_Amino_Acid_SequenceSingle letter amino acid representation of the sequencestring-
Three_Letter_Amino_Acid_SequenceThree letter amino acid representation of the sequence, including non-standard amino acids and chemical groupsstring-
Post_Translational_ModificationDetails of any post-translational modifications for endogenous peptidesstring-
Chemical_ModificationDetails of any chemical groups or modifications for synthetic peptidesstring-
Simplified_Molecular_Input_Line_Entry_SystemFor some peptides, the chemical structure is also given in canonical, isomeric Simplified Molecular Input Line Entry System (SMILES)string-
International_Chemical_Identifier_KeyA hashed version of the full International Chemical Identifier (InChI) designed for easy web searches of chemical compoundsstring-
Ligand_IdLigand_NameSpeciesEndogenous_or_Peptide_TypeSubunit_IdsSubunit_NamesIs_ApprovedIs_WithdrawnIs_LabelledIs_RadioactivePubChem_Substance_IdentifierPubChem_Compound_DatabaseUniProt_IdInternational_Non_Proprietary_NameSingle_Letter_Amino_Acid_SequenceThree_Letter_Amino_Acid_SequencePost_Translational_ModificationChemical_ModificationSimplified_Molecular_Input_Line_Entry_SystemInternational_Chemical_Identifier_Key
774vCCL4Other peptide135652633
655B-9958Other peptide135652008
1998R3/I5Other peptide135652176
816vMCC-IOther peptide135652634
815vMIP-IOther peptide135652635
7925HAS-NMUOther peptide249565608
9114JMR-132Other peptide315661199
5899lasso DOther peptide178102522
9442LV-2172Other peptide329968382
9067PL-3994Other peptide315661152