Expression Profiles For Proteins in Human Cancer Tissues

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This dataset covers the staining profiles for proteins in human tumor tissue based on immunohistochemistry using tissue microarrays. The data is based on The Human Protein Atlas version 16 and Ensembl version 83.38.

Complexity

The cancer tissue dataset contains a multitude of human cancer specimens representing the 20 most common forms of cancer, including breast-, colon-, prostate-, lung-, urothelial-, skin-, endometrial- and cervical cancer. Altogether 216 different cancer samples are used to generate protein expression profiles for all proteins using immunohistochemistry. The data is presented as pathology-based annotation of protein expression levels in tumor cells, along with the images underlying the annotation. This enables the identification of a potential protein signature for each given type of cancer and provides a starting point for further analyses of cancer type-specific proteins. Because the cancer atlas contains a large number of cancer samples the available protein profiles provide an excellent starting point for identifying new potential cancer biomarkers.

Date Created

2003

Last Modified

2016-12-04

Version

16

Update Frequency

Annual

Temporal Coverage

N/A

Spatial Coverage

United States

Source

John Snow Labs => The Human Protein Atlas, Ensembl

Source License URL

John Snow Labs Standard License

Source License Requirements

Publicly available and free for research application but citation is required. Permission asked for commercial uses

Source Citation

Human Protein Atlas available from www.proteinatlas.org

Keywords

Protein Staining Profiles, Human Tumor Tissue, Human Cancer Specimens, Potential Cancer Biomarkers, Tissue Microarray Data, Immunohistochemistry, Expression profiles of cancer tissues

Other Titles

Gene Expression Based on Immunohistochemistry of Cancer Tissue, Expression Profiles for Proteins Using Cancer Tissues

Name Description Type Constraints
Ensembl_Gene_IDGene ID by Ensemblstringrequired : 1
Gene_IDName assigned to gene.stringrequired : 1
Tumor_NameName of Tumor tissuestringrequired : 1
Level_of_StainingStaining valuestringrequired : 1
Patient_Staining_CountNumber of patients that stain for this staining valueintegerlevel : Ratio
Total_PatientsTotal amount of patients for this tumor typeintegerrequired : 1 level : Ratio
Ensembl_Gene_IDGene_IDTumor_NameLevel_of_StainingPatient_Staining_CountTotal_Patients
ENSG00000164458TgliomaLow12
ENSG00000039537C6gliomaLow10
ENSG00000042832TGgliomaLow11
ENSG00000047597XKgliomaLow12
ENSG00000062485CSgliomaLow11
ENSG00000090402SIgliomaLow11
ENSG00000103876FAHgliomaLow9
ENSG00000106804C5gliomaLow10
ENSG00000107159CA9gliomaLow9
ENSG00000110395CBLgliomaLow9