Others titles
- Chemicals Directly Contributing to Disease
- Drugs Contributing to Disease
- Do Chemicals Contribute to a Disease?
Keywords
- Drug List
- Chemical Preparation
- Drugs and Diseases
- Disease Symptoms Data
- Drugs Relationships
- Chemicals and Disease
Chemicals Contributing to Disease
This dataset consists of information that helps to determine if certain chemicals contribute to a disease.
Get The Data
- ResearchNon-Commercial, Share-Alike, Attribution Free Forever
- CommercialCommercial Use, Remix & Adapt, White Label Log in to download
Description
This dataset is created by Crowd Flower. Contributors at Crowd Flower read sentences in which both a chemical (like Aspirin) and a disease (or side-effect) were present. They then determined if the chemical directly contributed to the disease or caused it. Dataset includes chemical names, disease name, and aggregated judgements of five (as opposed to the usual three) contributors.
About this Dataset
Data Info
Date Created | 2016-11-22 |
---|---|
Last Modified | 2018-05-27 |
Version | 2018-05-27 |
Update Frequency |
Biennial |
Temporal Coverage |
N/A |
Spatial Coverage |
N/A |
Source | John Snow Labs; Data.World, Crowd Flower; |
Source License URL | |
Source License Requirements |
N/A |
Source Citation |
N/A |
Keywords | Drug List, Chemical Preparation, Drugs and Diseases, Disease Symptoms Data, Drugs Relationships, Chemicals and Disease |
Other Titles | Chemicals Directly Contributing to Disease, Drugs Contributing to Disease, Do Chemicals Contribute to a Disease? |
Data Fields
Name | Description | Type | Constraints |
---|---|---|---|
Unit_Id | Unique ID assigned to each entry | integer | level : Nominalrequired : 1 |
Is_Unit_Ambiguous | Whether or not the unit is ambiguous. | boolean | required : 1 |
Is_Unit_State_Finalized | State of the unit, either finalized, or not finalized | boolean | required : 1 |
Trusted_Judgements | Number of people who made their judgements against the unit to be correct or ambiguous. | integer | level : Ratio |
Last_Judgement_Date | Date and time when the last trusted judgement was made. | datetime | - |
Judgement_Remarks | Remarks given to each unit | string | - |
Patient_Relation_Type | Type of association that the patient had with the drug. | string | required : 1 |
Percent_Patient_Relation_Type | Percentage of association that the patient had with the drug. | number | level : Ratiorequired : 1 |
Chemical_Id | Unique ID assigned to the chemical. | string | required : 1 |
Chemical_Name | Name of the chemical | string | required : 1 |
Disease_Id | Unique ID assigned to the disease. | string | required : 1 |
Disease_Name | Name of the disease | string | required : 1 |
Form_Sentence | Sentence mentioned on the form filled by the patients | string | required : 1 |
Sentence_Id | Unique ID assigned to the sentence | string | - |
Relation_Pair_Id | ID created by combining Chemical_Id, Disease_Id and Sentence_Id | string | required : 1 |
Patient_Relation_Type_Verification | Verification done by the contributor | string | - |
Patient_Relation_Type_Verification_Reason | Reason of verification provided by the contributor | string | - |
Data Preview
Unit Id | Is Unit Ambiguous | Is Unit State Finalized | Trusted Judgements | Last Judgement Date | Judgement Remarks | Patient Relation Type | Percent Patient Relation Type | Chemical Id | Chemical Name | Disease Id | Disease Name | Form Sentence | Sentence Id | Relation Pair Id | Patient Relation Type Verification | Patient Relation Type Verification Reason |
770955372 | True | False | 9 | Direct | 0.4463 | D012701 | 5-HT | D011605 | psychotic disorders | These animal models were considered to reflect the positive symptoms of schizophrenia, and the above evidence suggests that altered 5-HT6 receptors are involved in the pathophysiology of psychotic disorders. | 20705401_4 | 20705401_D012701_D011605 | No Relation | The receptors to 5-HT6 are related to psychotic disorders, not 5-HT itself. | ||
770955373 | True | False | 11 | No Relation | 0.9181 | D010396 | D-penicillamine | D012594 | localized scleroderma | Case reports of 11 patients with severe, extensive localized scleroderma who were treated with D-penicillamine are summarized in this article. | 2334179_3 | 2334179_D010396_D012594 | No Relation | D-penicillamine was used to treat the patients. | ||
770955374 | True | False | 12 | No Relation | 1.0 | D015016 | yohimbine | D019964 | affective disorders | METHOD: Six patients with either obsessive compulsive disorder, trichotillomania, anxiety, or affective disorders who suffered sexual side effects after treatment with serotonin reuptake blockers were given yohimbine on a p.r.n. basis in an open clinical trial. | 1535072_4 | 1535072_D015016_D019964 | No Relation | The sentence says the affective disorders were caused by "serotonin reuptake blockers". Yohimbine was used to try and treat the patients. | ||
770955375 | True | False | 11 | No Relation | 1.0 | D002118 | calcium | D013035 | muscle spasms | While severe hypokalemia may cause muscle weakness, severe hypomagnesemia is associated with muscle spasms and tetany which cannot be corrected by potassium and calcium supplementation alone (1,2). | 8492347_2 | 8492347_D002118_D013035 | No Relation | The sentence says calcium supplementation cannot be used to treat muscle spasms and tetany. | ||
770955376 | True | False | 9 | No Relation | 0.8905 | D064730 | dexrazoxane | D006402 | hematologic toxicity | Clinical trials in patients with brain metastases combining dexrazoxane and high doses of etoposide is ongoing with the aim of improving efficacy without aggravating hematologic toxicity. | 15897593_8 | 15897593_D064730_D006402 | No Relation | Dexrazoxane is being used to try and make the patients better without making hematologic toxicity worse. The sentence does not say that dexrazoxane causes hematologic toxicity. | ||
770955377 | True | False | 15 | No Relation | 1.0 | D003404 | creatinine | D006973 | hypertension | We used time-to-event analysis to identify potential predictors of decrease in renal function including age, baseline ejection fraction, baseline creatinine, low systolic blood pressure (<100 mm Hg), history of hypertension, diabetes, and use of antiplatelet, diuretic, and beta-blocker therapy. | 10539815_7 | 10539815_D003404_D006973 | No Relation | Creatinine and hypertension were studied as potential predictors of decreased renal (kidney) function. | ||
770955378 | True | False | 14 | No Relation | 1.0 | C071741 | remifentanil | D010146 | pain | CONCLUSIONS: During induction of anaesthesia with TCI of propofol and remifentanil, a significant reduction in propofol infusion pain was achieved without significant complications by prior administration of remifentanil at a target Ce of 4 ng ml(-1). | 18006530_11 | 18006530_C071741_D010146 | No Relation | Remifentanil reduces the pain caused by propofol. | ||
770955379 | True | False | 11 | Direct | 0.828 | C012052 | amisulpride | D006973 | hypertensive | CONCLUSIONS: As of March 24, 2005, this is the first reported case of amisulpride- and tiapride-induced hypertensive crisis in a patient with pheochromocytoma. | 15811908_7 | 15811908_C012052_D006973 | Direct | This sentence talks about the first case of amisulpride induced hypertensive crisis. | ||
770955380 | True | False | 10 | Direct | 0.6143 | D002211 | capsaicin | D010146 | painful | A small amount of capsaicin was administered subcutaneously in the right forehead to evoke a burning painful sensation in the first division of the trigeminal nerve. | 9514561_4 | 9514561_D002211_D010146 | Direct | Capsaicin (the chemical that makes chilis spicy), when put under your skin, causes pain. | ||
770955381 | True | False | 16 | No Relation | 1.0 | D003630 | daunorubicin | D000163 | AIDS | We report a non-randomized Phase II clinical trial to assess the efficacy and safety of liposomal daunorubicin (DaunoXome) in the treatment of AIDS related Kaposi's sarcoma. | 8305357_1 | 8305357_D003630_D000163 | No Relation | Daunorubicin is being studied as a way to treat AIDS related Kaposi's sarcoma. |